'Student's' t Test (For Paired
Samples)
Use this test to compare two small sets of quantitative
data when data in each sample set are related in
a special way.
Criteria
- The number of points in each data set must
be the same, and they must be organized in pairs,
in which there is a definite relationship between
each pair of data points
- If the data were taken as random samples,
you must use the independent test even if the
number of data points in each set is the same
- Even if data are related in pairs, sometimes
the paired t is still inappropriate
- Here's a simple rule to determine if the paired
t must not be used - if a given data point in
group one could be paired with any data point
in group two, you cannot use a paired t test
Examples
The paired t test is generally used when measurements
are taken from the same subject before and after
some manipulation such as injection of a drug.
For example, you can use a paired t test to determine
the significance of a difference in blood pressure
before and after administration of an experimental
pressor substance. You can also use a paired t
test to compare samples that are subjected to different
conditions, provided the samples in each pair are
identical otherwise. For example, you might test
the effectiveness of a water additive in reducing
bacterial numbers by sampling water from different
sources and comparing bacterial counts in the treated
versus untreated water sample. Each different water
source would give a different pair of data points.
The value of the paired t test is best demonstrated
in an example. Suppose patient 1 responds to a
drug with a 5 mm Hg rise in mean blood pressure
from 100 to 105. Patient 2 has a 30 mm Hg rise,
from 90 to 120. Likewise for several other subjects.
The response to the drug varied widely, but all
patients had one thing in common - there was always
a rise in blood pressure. Some of that experimental
error is avoided by the paired t test, which likely
will pick up a significant difference. The independent
test, which would be improperly applied in this
case, would not be able to reject the null hypothesis.
Be certain that use of the paired t test is valid
before applying it to real data. An applied statistics
course or supervision of a qualified mentor may
provide the experience you need.
Some spreadsheet programs include the paired
t test as a built-in option. Even without a built-in
option, is is so easy to set up a spreadsheet to
do a paired t test that it may not be worth the
expense and effort to buy and learn a dedicated
statistics software program, unless more complicated
statistics are needed.
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