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Roles and targets of microRNAs in Arabidopsis
Bonnie Bartel, Professor
Department of Biochemistry and Cell Biology
bartel@rice.edu


MicroRNAs are recently discovered ~21-nucleotide regulatory RNAs that are processed from hairpin precursors by Dice-like enzymes.  MicroRNAs can negatively regulate gene expression by attenuating translation, which is prevalent in animal systems, or by directing mRNA cleavage (see figure), which can occur in plants. 

In collaboration with the laboratory of David Bartel of the Whitehead Institute, we are studying the occurrence and functions of these tiny RNAs during Arabidopsis development.

(Press release on miR164; Press release on miR160) Diana Dugas

Lab members with microRNA projects:

Former Graduate Student:

Diana Dugas

We gratefully acknowledge support for this research from the NIH and the G. Harold and Leila Y. Mathers Charitable Foundation.

Publications on microRNAs:

Other Bartel lab projects:
Auxin signaling, conjugates, peroxisomes, 
triterpenes, IBA

Criteria for annotation of plant microRNAs.
Meyers, B.C, Axtell, M.J., Bartel, B., Bartel, D.P., Baulcombe, D., Bowman, J.L., Cao, X., Carrington, J.C., Chen, X., Green, P.J., Griffiths-Jones, S., Jacobsen, S.E., Mallory, A.C., Martienssen, R.A., Poethig, R.S., Qi, Y., Vaucheret, H., Voinnet, O., Watanabe, Y., Wiegel, D., Zhu, J.K. (2008) The Plant Cell 20, 3186-3190.
Abstract; full text; PDF

Sucrose induction of Arabidopsis miR398 represses two Cu/Zn superoxide dismutases.
Dugas, D.V. and Bartel, B. (2008) Plant Molecular Biology 67, 403-417.
Abstract; full text

MicroRNAs and their regulatory roles in plants.
Jones-Rhoades, M.W., Bartel, D.P., and Bartel, B. (2006) Annual Review of Plant Biology 57, 19-53.
Abstract; full text

MicroRNAs directing siRNA biogenesis.
Bartel, B. (2005) Nature Structural & Molecular Biology12, 569-571.
abstract; full text

MicroRNA-directed regulation of Arabidopsis AUXIN RESPONSE FACTOR17 is essential for proper development and modulates expression of early auxin response genes.
Mallory, A.C., Bartel, D.P., and Bartel, B. (2005) Plant Cell, 17, 1360-1375. (On the cover)
Abstract; full text

MicroRNA regulation of gene expression in plants.
Dugas, D.V. and Bartel, B. (2004) Current Opinion in Plant Biology 7, 512-520.
Abstract

MicroRNA regulation of NAC-domain targets is required for proper formation and separation of adjacent embryonic, vegetative, and floral organs.
Mallory, A.C., Dugas, D.V., Bartel, D.P., and Bartel, B. (2004) Current Biology 14, 1035-1046. (On the cover)
Abstract; full text

MicroRNAs.  At the root of plant development? 
Bartel, B. and Bartel, D.P. (2003) Plant Physiology 132, 709-717.
Full text; PDF

A uniform system for microRNA annotation.
Ambros, V., Bartel, B., Bartel, D.P., Burge, C.B., Carrington, J.C., Chen, X., Dreyfuss, G., Eddy, S.R., Griffiths-Jones, S., Marshall, M., Matzke, M., Ruvkun, G., and Tuschl, T. (2003) RNA 9, 277-279.
Abstract; full text; PDF

Prediction of plant microRNA targets.
Rhoades, M.W., Reinhart. B.J., Lim, L.P., Burge, C.B., Bartel, B., and Bartel, D.P. (2002) Cell 110, 513-520.
Abstract; full text; PDF

MicroRNAs in plants.
Reinhart, B.J., Weinstein E.G., Rhoades M.W., Bartel B., Bartel D.P. (2002) Genes and Development 16, 1616-1626.
Abstract; full text; PDF


Links:
microRNA cloning protocol from David Bartel lab
microRNA registry at the Rfam database of non-coding RNA families
Database of Arabidopsis miRNAs and siRNAs (from James Carrington lab)
TAIR (The Arabidopsis Information Resource)
T-DNA Express at the Salk Institute (insertion lines)
American Society of Plant Biologists (Plant Cell, Plant Physiology)
Center for Plant Science at Rice University
Biochemistry and Cell Biology Department

Biochemistry