vkorc1 mutations affect blood coagulation
One medical application of our work will be to provide a more complete collection of genes that may mediate warfarin-drug interactions.
Moreover, we study the phenotype of vkorc1 mutant lab strains of rats and mice, because, blood coagulation aside, vitamin K-related disease in humans is a widely discussed possibility. However, the manner in which such disease may manifest itself is a subject of speculation.
We are examining the vkorc1 mutant rat and mouse in detail for potential health issues due to vitamin K deficiency.
vkorc1 mutant rats display calcification of the aorta walls
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MRI of a warfarin resistant vkorc1 mutant rat.
microCT scan of the femurs of warfarin resistant vkorc1 mutant rats.