Genetics of Adaptation :
The detection of adaptations at the level of genes is another area of interest. As our study system we utilize rat populations resistant to anticoagulant rodenticides (e.g. warfarin) in Germany and across the globe. Using bioinformatics and gene expression assays we isolate all genes that potentially could interact with warfarin and examine how the various populations have adapted to warfarin exposure. We also plan to travel back in time and use ancient DNA technologies to study the origin of these molecular adaptations. Finally, we utilize the system to further develop tests for natural selection on genes.
Detecting the signature of natural selection for warfarin
rodenticide resistance on rat chromosome 1