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2003

2003

 V.I. Sikavitsas, G.N. Bancroft, H.L. Holtorf, J.A. Jansen, and A.G. Mikos, "Mineralized Matrix Deposition by Marrow Stromal Osteoblasts in 3D Perfusion Culture Increases with Increasing Fluid Shear Forces," Proceed. Natl. Acad. Sci. USA, 100, 14683-14688 (2003).

 J.S. Blum, M.A. Barry, A.G. Mikos, and J.A. Jansen, "In Vivo Evaluation of Gene Therapy Vectors in Ex Vivo Derived Marrow Stromal Cells for Bone Regeneration in a Rat Critical Size Calvarial Defect Model," Human Gene Therapy, 14, 1689-1701 (2003).

C.G. Ambrose, G.R. Gogola, T.A. Clyburn, A.K. Raymond, A.S. Peng, and A.G. Mikos, "Antibiotic Microspheres: Preliminary Testing for Potential Treatment of Osteomyelitis," Clin. Orthop. Rel. Res., 415, 279-285 (2003).

K. Tanahashi and A.G. Mikos, "Effect of Hydrophilicity and Agmatine Modification on Degradation of Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels," J. Biomed. Mater. Res. Part A, 67A, 1148-1154 (2003).

J.S. Blum, M.A. Barry, and A.G. Mikos, "Bone Regeneration through Transplantation of Genetically Modified Cells," Clin. Plast. Surg., 30, 611-620 (2003).

V.I. Sikavitsas, J. van den Dolder, G.N. Bancroft, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos, "Influence of the In Vitro Culture Period on the In Vivo Performance of Cell/Titanium Bone Tissue Engineered Constructs Using a Rat Cranial Critical Size Defect Model," J. Biomed. Mater. Res. Part A, 67A, 944-951 (2003).

J.S. Temenoff, H. Shin, D.E. Conway, P.S. Engel, and A.G. Mikos, "In Vitro Cytotoxicity of Redox Radical Initiators for Crosslinking of Oligo(Poly(Ethylene Glycol) Fumarate) Macromers," Biomacromolecules, 4, 1605-1613 (2003).

K. Tanahashi and A.G. Mikos, "Protein Adsorption and Smooth Muscle Cell Adhesion on Biodegradable Agmatine-Modified Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels," J. Biomed. Mater. Res. Part A, 67A, 448-457 (2003).

Z. Lalani, M. Wong, E.M. Brey, A.G. Mikos, and P.J. Duke, "Spatial and Temporal Localization of Transforming Growth Factor-b1, Bone Morphogenetic Protein-2, and Platelet-Derived Growth Factor-A in Healing Tooth Extraction Sockets in a Rabbit Model," J. Oral Maxillofac. Surg., 61, 1061-1072 (2003).

J.S. Temenoff, E.S. Steinbis, and A.G. Mikos, "Effect of Drying History on Swelling Properties and Cell Attachment to Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels for Guided Tissue Regeneration Applications," J. Biomater. Sci., Polym. Ed., 14, 989-1004 (2003).

J.P. Fisher, T.A. Holland, D. Dean, and A.G. Mikos, "Photoinitiated Crosslinking of the Biodegradable Polyester Poly(Propylene Fumarate). Part II: In Vitro Degradation," Biomacromolecules, 4, 1335-1342 (2003).

J.P. Fisher, M.D. Timmer, T.A. Holland, D. Dean, P.S. Engel, and A.G. Mikos, "Photoinitiated Cross-Linking of the Biodegradable Polyester Poly(Propylene Fumarate). Part I: Determination of Network Structure," Biomacromolecules, 4, 1327-1334 (2003).

M.D. Timmer, C. Carter, C.G. Ambrose, and A.G. Mikos, "Fabrication of Poly(Propylene Fumarate)-Based Orthopaedic Implants by Photo-Crosslinking Through Transparent Silicone Molds," Biomaterials, 24, 4707-4714 (2003).

M.E. Gomes, V.I. Sikavitsas, E. Behravesh, R.L. Reis, and A.G. Mikos, "Effect of Flow Perfusion on the Osteogenic Differentiation of Bone Marrow Stromal Cells Cultured on Starch-Based Three-Dimensional Scaffolds," J.Biomed. Mater. Res. Part A, 67A, 87-95 (2003).

T.A. Holland, Y. Tabata, and A.G. Mikos, "In Vitro Release of Transforming Growth Factor-b1 from Gelatin Microparticles Encapsulated in Biodegradable, Injectable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels," J. Controlled Release, 91, 299-313 (2003).

P.Q. Ruhe, E.L. Hedberg, N.T. Padron, P.H. Spauwen, J.A. Jansen , and Mikos AG, "rhBMP-2 release from injectable poly(DL-lactic-co-glycolic acid)/calcium-phosphate cement composites," J. Bone Joint Surg. Am., 85-A Suppl 3, 75-81 (2003).

J.K. Tessmar, A.G. Mikos, and A. Goepferich, "The Use of Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Derived Copolymers for the Rapid Creation of Biomimetic Surfaces," Biomaterials, 24, 4475-4486 (2003).

E. Behravesh, V.I. Sikavitsas, and A.G. Mikos, "Quantification of Ligand Surface Concentration of Bulk-Modified Biomimetic Hydrogels," Biomaterials, 24, 4365-4374 (2003).

H. Shin, S. Jo, and A.G. Mikos, "Biomimetic Materials for Tissue Engineering," Biomaterials, 24, 4353-4364 (2003).

M.D. Timmer, C.G. Ambrose, and A.G. Mikos, "Evaluation of Thermal- and Photo-Crosslinked Biodegradable Poly(Propylene Fumarate)-Based Networks," J. Biomed. Mater. Res. Part A, 66A, 811-818 (2003).

E. Behravesh and A.G. Mikos, "Three-Dimensional Culture of Differentiating Marrow Stromal Osteoblasts in Biomimetic Poly(Propylene Fumarate-co-Ethylene Glycol)-Based Macroporous Hydrogels," J. Biomed. Mater. Res. Part A, 66A, 698-706 (2003).

M.D. Timmer, H. Shin, R.A. Horch, C.G. Ambrose, and A.G. Mikos, "In Vitro Cytotoxicity of Injectable and Biodegradable Poly(Propylene Fumarate)-Based Networks: Unreacted Macromers, Cross-Linked Networks, and Degradation Products," Biomacromolecules, 4, 1026-1033 (2003).

D. Dean, N.S. Topham, S.C. Meneghetti, M.S. Wolfe, K. Jepsen, S. He, J.E.-K. Chen, J.P. Fisher, M. Cooke, C. Rimnac, and A.G. Mikos, "Poly(Propylene Fumarate) and Poly(DL-Lactic-co-Glycolic Acid) as Scaffold Materials for Solid and Foam-Coated Composite Tissue-Engineered Constructs for Cranial Reconstruction," Tissue Eng., 9, 495-504 (2003).

J. van den Dolder, G.N. Bancroft, V.I. Sikavitsas, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen, "Effect of Fibronectin- and Collagen I-Coated Titanium Fiber Mesh on Proliferation and Differentiation of Osteogenic Cells," Tissue Eng., 9, 505-515 (2003).

G.N. Bancroft, V.I. Sikavitsas, and A.G. Mikos, "Design of a Flow Perfusion Bioreactor System for Bone Tissue-Engineering Applications," Tissue Eng., 9, 549-554 (2003).

H. Shin, Q. Ruhé, A.G. Mikos, and J.A. Jansen, "In vivo bone and soft tissue response to injectable, biodegradable oligo(poly(ethylene glycol) fumarate) hydrogels," Biomaterials, 24, 3201-3211 (2003).

M.D. Timmer, R.A. Horch, C.G. Ambrose, and A.G. Mikos, "Effect of Physiological Temperature on the Mechanical Properties and Network Structure of Biodegradable Poly(Propylene Fumarate)-Based Networks," J. Biomater. Sci., Polym. Ed., 14, 369-382 (2003).

H. Shin, J.S. Temenoff, and A.G. Mikos, "In Vitro Cytotoxicity of Unsaturated Oligo(Poly(Ethylene Glycol) Fumarate) Macromers and their Crosslinked Hydrogels," Biomacromolecules, 4, 552-560 (2003).

A.K. Shung, E. Behravesh, S. Jo, and A.G. Mikos, "Crosslinking Characteristics of and Cell Adhesion to an Injectable Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogel Using a Water-Soluble Crosslinking System," Tissue Eng., 9, 243-254 (2003)

E. Behravesh, K. Zygourakis, and A.G. Mikos, "Adhesion and Migration of Marrow-Derived Osteoblasts on Injectable In Situ Crosslinkable Poly(Propylene Fumarate-Co-Ethylene Glycol) Based Hydrogels with a Covalently Linked RGDS Peptide," J. Biomed. Mater. Res. Part A, 65A, 261-271 (2003).

E. Lieb, J. Tessmar, M. Hacker, C. Fischbach, D. Rose, T. Blunk, A.G. Mikos, A. Göpferich, and M.B. Schulz, "Poly(D,L-Lactic Acid)-Poly(Ethylene Glycol)-Monomethyl Ether Diblock Copolymers Control Adhesion and Osteoblastic Differentiation of Marrow Stromal Cells," Tissue Eng., 9, 71-84 (2003).

J. van den Dolder, G.N. Bancroft, V.I. Sikavitsas, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos, "Flow Perfusion Culture of Marrow Stromal Osteoblasts in Titanium Fiber Mesh," J. Biomed. Mater. Res. Part A, 64A, 235-241 (2003).

M.N. Cooke, J.P. Fisher, D. Dean, C. Rimnac, and A.G. Mikos, "Use of Stereoliphography to Manufacture Critical-Sized 3D Biodegradable Scaffolds for Bone Ingrowth," J. Biomed. Mater. Res. Part B: Appl. Biomater., 64B, 65-69 (2003).

T.A. Holland and A.G. Mikos, "Advances in Drug Delivery for Articular Cartilage," J. Controlled Release, 86, 1-14 (2003).

M.D. Timmer, C.G. Ambrose, and A.G. Mikos, "In Vitro Degradation of Polymeric Networks of Poly(Propylene Fumarate) and the Crosslinking Macromer Poly(Propylene Fumarate)-Diacrylate," Biomaterials, 24, 571-577 (2003).