Metabolic Engineering and Synthetic & Systems Biology Laboratory
Research
Metabolic Engineering
Metabolic Engineering (ME) has been defined as “the improvement of cellular activities by manipulation of enzymatic, transport, and regulatory functions of the cell with the use of recombinant DNA technology”; (Bailey, J. E. (1991). Science, 252: 1668-1674). ME is a proven, powerful approach to studying and optimizing fermentation processes. [Read More]
Functional Genomics and Systems Biology
The ultimate goal in studying a biological system is to unravel the underlying mechanisms that link a specific genotype to a correspondent phenotype: i.e. how the genetic information (genotype) yields a specific set of properties (phenotype) under given environmental conditions. [Read More]
Microbial & Cell Cultures
There are two general steps involved in the development of a microbial fermentation process: (1) the development of a biocatalyst that efficiently catalyzes the desired biochemical reaction(s) (accomplished through Metabolic Engineering), and (2) the identification of the optimum culture conditions and the appropriate fermentation system. [Read More]