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Metabolic Engineering and Biomanufacturing Laboratory

Elliot Miller, Ph.D.


B.S., Microbiology and Cell Science, University of Florida, 2004.

Ph.D., Microbiology and Cell Science, University of Florida, 2009.





Project Description

Current work focuses on the production of non-native products in Escherichia coli using a homologous metabolic engineering approach.


Dellomonaco, C., J.M. Clomburg, E.N. Miller, and Ramon Gonzalez. 2011.  Engineered reversal of the beta-oxidation cycle as a metabolic platform for the combinatorial synthesis of advanced fuels and chemicals. Nature (doi:10.1038/nature10333).
Wang, X.*, E.N. Miller*, Lorraine Yomano, Xueli Zhang, K. Shanmugam, and Lonnie Ingram.  2011.  Overexpression of NADH-dependent oxidoreductase fucO increases furfural tolerance in Escherichia coli strains engineered for the production of ethanol and lactate.  Applied and Environmental Microbiology (#AEM05008-11R1).  *denotes equal author contributions.
Nieves I.U., C.C. Geddes, E.N. Miller, M.T. Mullinnix, R.W. Hoffman, Z. Fu, Z. Tong, L.O. Ingram.  2011.  Effect of reduced sulfur compounds on the fermentation of phosphoric acid pretreated sugarcane bagasse by ethanologenic Escherichia coli.  Bioresource Technology 102(8):5145-5152.
Geddes, C., E.N. Miller, Mike Mullinex, Ismael Nieves, and L.O. Ingram.  2010.  Simplified process for ethanol production from sugarcane bagasse using hydrolysate-resistant Escherichia coli strain MM160.  Bioresource Technology 102(3):2702-2711.
Turner, P.C., E.N. Miller, L.R. Jarboe, , C.L. Baggett, K.T. Shanmugam, and L.O. Ingram.  2010.  YqhC regulates transcription of the adjacent Escherichia coli genes yqhD and dkgA that are involved in furfural tolerance.  Journal of Industrial Microbiology & Biotechnology 2011 38(3):431-439.
Miller, E.N., P.C. Turner, L.R. Jarboe, and L.O. Ingram.  2009.  Genetic changes that increase 5-hydroxymethyl furfural resistance in ethanol-producing Escherichia coli LY180. Biotechnology Letters 32(5):661-667.
Miller, E.N., L.R. Jarboe, P.C. Turner, P. Pharkya, L.P. Yomano, S.W. York, D. Nunn, K.T. Shanmugam, and L.O. Ingram.  2009.  Furfural inhibits growth by limiting sulfur assimilation in ethanologenic Escherichia coli strain LY180.  Applied and Environmental Microbiology 75:6132-6141.
Miller, E.N., L.R. Jarboe, L.P. Yomano, S.W. York, K.T. Shanmugam, and L.O. Ingram. 2009.  Silencing of NADPH-dependent oxidoreductases (yqhD and dkgA) in furfural-resistant ethanologenic Escherichia coli.  Applied and Environmental Microbiology 75:4315-4323.
Miller, E.N., and L.O. Ingram. 2008.  Sucrose and overexpression of trehalose biosynthetic genes (otsBA) increase desiccation tolerance of recombinant Escherichia coli.  Biotechnology Letters 30:503-508.
Miller, E.N., and L.O. Ingram. 2007. Combined effect of betaine and trehalose on osmotic tolerance of Escherichia coli in mineral salts medium.  Biotechnology Letters 29:213-217.


Contact Information

Abercrombie Lab, C124
Rice University
6100 Main Street MS-362
Houston, TX, 77005
Fax (713) 348-5478