Wu H, San
KY. Engineering Escherichia coli
for odd straight medium chain free fatty acid production. Appl Microbiol
Biotechnol.98(19):8145-54 (2014) DOI: 10.1007/s00253-014-5882-5
Wu H, Tuli L, Bennett GN, San KY. Metabolic transistor
strategy for controlling electron transfer chain activity in Escherichia
coli. Metab Eng. 28:159-168 (2015) doi:
10.1016/j.ymben.2015.01.002
Thakker C,
Martinez I, San KY, Bennett GN. Metabolic engineering of carbon and redox
flow in the production of small organic acids, J Ind
Microbiol Biotechnol. 42: 403-422 (2015) PMID:
25502283; doi: 10.1007/s10295-014-1560-y.
Wu H, Lee
J, Karanjikar M, San KY. Simultaneous utilization
of glucose and mannose from woody hydrolysate for free fatty acid
production by metabolically engineered Escherichia coli, Bioresource Tehncology, 185:431-435
(2015) doi: 10.1016/j.biortech.2015.03.007
Wu H, Tuli L, Bennett GN, San KY. Metabolic Control of
Respiratory Levels in Coenzyme Q Biosynthesis-Deficient Escherichia coli
Strains Leading to Fine-tune Aerobic Lactate Fermentation. Biotechnol Bioeng. 112(8):1720-6 (2015) doi:
10.1002/bit.25585
Wang D, Wu
H, Thakker C, Beyersdorf J, Bennett GN, San KY.
Efficient free fatty acid production in engineered Escherichia coli strains
using soybean oligosaccharides as feedstock. Biotechnol Prog.
31(3):686-694 (2015) doi: 10.1002/btpr.2092.
Wang D,
Thakker C, Liu P, Bennett GN, San KY. Efficient Production of Free Fatty
Acids from Soybean Meal Carbohydrates. Biotechnology and Bioengineering,
112(11):2324-33. doi:
10.1002/bit.25633 (2015).
Wu H, San KY.
Efficient odd straight medium chain free fatty acid production by
metabolically engineered Escherichia coli. Biotechnol Bioeng.
111(11):2209-19 (2014) doi: 10.1002/bit.25296
Wu H, Karanjikar M, San KY. Metabolic engineering of
Escherichia coli for efficient free fatty acid production from glycerol. Metab Eng.25:82-91 (2014) doi:
10.1016/j.ymben.2014.06.009
Wu H, Lee
J, Karanjikar M, San KY. Efficient free fatty
acid production from woody biomass hydrolysate using metabolically
engineered Escherichia coli. Bioresource
Technology. 169:119-25 (2014) doi:
10.1016/j.biortech.2014.06.092
Wu H, San
KY. Engineering Escherichia coli for odd straight medium chain free fatty
acid production. Appl Microbiol
Biotechnol.98(19):8145-54 (2014) DOI: 10.1007/s00253-014-5882-5
Li M,
Zhang X, Argawal A, San K-Y. Effect of acetate
formation pathway and long chain fatty acid CoA-ligase on the free fatty
acid production in E. coli expressing acyl-ACP thioesterase from Ricinus communis. Metabolic
Engineering, 14: 380-387 (2012). PMID: 22480945
Park J,
Rodriguez-Moya M, Li M, Pichersky E, San KY,
Gonzalez R. Synthesis of methyl ketones by metabolically engineered
Escherichia coli. J Ind Microbiol
Biotechnol. 39(11):1703-12 (2012). PMID: 22850984
Thakker C,
Bennett GN, San KY. Production of succinic acid using soluble sugars of
feedstock soybeans by engineered E. coli strains under aerobic fermentation
conditions. Bioresource Technology 130: 398-405
(2013). PMID: 23313685
Wang Y,
San KY, Bennett GN. Improvement of NADPH Bioavailability in Escherichia
coli through the use of Phosphofructokinase Deficient Strains. Appl Microbiol Biotechnol.
97(15):6883-93, (2013). PMID: 23558585
Wang Y,
San KY, Bennett GN. Cofactor engineering for advancing chemical
biotechnology. Curr Opin
Biotechnol. 24:1-6 (2013) PMID: 23611567
Joanna J,
Martinez I, Wang Y, Bennett GN, San KY. Metabolic engineering and
transhydrogenase effects on NADPH availability in Escherichia coli.
Biotechnology Progress. 29:1124-1130 (2013) PMID: 23794523
Wang Y,
San KY, Bennett GN. Improvement of NADPH Bioavailability in Escherichia
coli by Replacing NAD+ Dependent Glyceraldehydes-3-phosphate Dehydrogenase GapA with NADP+ Dependent GapB
from Bacillus subtilis and NAD Kinase. Journal of Industrial Microbiology
& Biotechnology, 40(12):1449-60 (2013)
Balzer GJ,
Thakker C, Bennett GN, San KY. Metabolic engineering of E. coli to minimize
byproduct formate and improving succinate productivity through increasing
NADH availability by heterologous expression of NAD+-dependent formate dehydrogenase.
Metabolic Engineering. 20:1-8 (2013). PMID: 23876411
Thakker C,
Martinez I, San K-Y, Bennett GN. Succinate production in Escherichia coli.
Biotechnol J. 7:213-224 (2012).
Zhang X, Argawal A, San K-Y. Improving fatty acid production in
Escherichia coli through the overexpression of malonyl
coA-Acyl carrier protein transacylase.
Biotechnology Progress, 28:60-65 (2012)
Zhu J,
Sanchez A, San K-Y, Bennett GN. Manipulating Respiratory Levels in
Escherichia coli for Aerobic Formation of Reduced Chemical Products.
Metabolic Engineering, 13:704-712 (2011).
Zhang X,
Li M, Argawal A, San K-Y. Efficient free fatty
acid production in Escherichia coli using plant acyl-ACP thioesterases. Metabolic Engineering, 13:713-722
(2011).
Wang J,
Zhu J, Bennett GN, San K-Y. Succinate production from sucrose by metabolic
engineered Escherichia coli strains under aerobic conditions. Biotechnology
Progress, 27: 1242-1247 (2011). DOI: 10.1002/btpr.661
Zhu J,
Thakker C, San K-Y, Bennett GN. Effect of culture operating conditions on
succinate production in a multiphase fed-batch bioreactor using an
engineered Escherichia coli strain. Applied Microbiology and Biotechnology,
92(3):499-508 (2011). PMID: 21667087
Martinez
I, Bennett GN, San K-Y. Culture conditions impact on succinate production
by a high succinate producing Escherichia coli strain. Biotechnology
Progress, 27: 1225-1231 (2011). DOI: 10.1002/btpr.641
Chung IM,
Kim E-H, Li M, Peebles CAM, Sung W-S, Song H-K, Ahn
J-K, San K-Y. Screening sixty-four cultivars Catharanthus
roseus for the production of vindoline,
catharanthine and serpentine. Biotechnology
Process, 27: 937-943 (2011).
Thakker C,
Zhu J, San K-Y, Bennett GN. Heterologous pycA
gene expression under various natural and engineered promoters in
Escherichia coli for improved succinate production. Journal of
Biotechnology, 155(2):236-43 (2011).
Li M,
Peebles CAM, Shanks JV, San K-Y. Effect of sodium nitroprusside on growth
and terpenoid indole alkaloid production in Catharanthus roseus hairy root
cultures. Biotechnology Progress, 27:625-630 (2011).
Wang J,
Zhu J, Bennett GN, San K-Y. Succinate production from different carbon
sources under anaerobic conditions by metabolic engineered Escherichia coli
strains. Metabolic Engineering, 13:328-35 (2011).
Peebles
CAM, Sander GW, Hughes EH, Peacock R, Shanks JV, San K-Y. The expression of
1-deoxy-D-xylulose synthase and geraniol 10-hydroxylase or anthranilate
synthase increases terpenoid indole alkaloid
accumulation in Catharanthus roseus
hairy roots. Metabolic Engineering, 13:234-40 (2011).
Martinez
I, Bennett GN, San K-Y. Metabolic impact of the level of aeration during
cell growth on anaerobic succinate production by an engineered Escherichia
coli strain. Metabolic Engineering, 12(6):499-509 (2010)
Nikel, P. I.,
Zhu, J., San, K.-Y., Mendez, B. S., and Bennett, G. N. Metabolic flux
analysis of carbon catabolism in Escherichia coli creB
and arcA mutants based on 13C-labeling
experiments under microaerobic conditions, J. Bacteriology, 191:5538-5548
(2009).
Dittrich,
C.R., Bennett, G.N., San, K.-Y., Metabolic Engineering of the anaerobic
central metabolic pathway in Escherichia coli for the simultaneous
anaerobic production of isoamyl acetate and
succinic acid, Biotechnology Progress, 25(5):1304-1309 (2009).
Peebles,
C.A.M., Hughes, E., Shanks, J.V., and San, K.-Y., Transcriptional response
of the terpenoid indole alkaloid pathway to the
overexpression of ORCA3 along with jasmonic acid
elicitation of Catharanthus roseus
hairy roots over time, Metabolic Engineering, 11:76-86 (2009).
Bennett G.
N., & San, K.-Y. Engineering E. coli Central Metabolism for Enhanced
Primary Metabolite Production. Chaper 17 in
Systems Biology and Biotechnology of E. coli. S. Y. Lee, Ed, Springer
351-375 (2009).
Peebles,
C.A.M., Sander, G.W., Li, M., Shanks, J.V., and San, K.-Y., Five year
maintenance of the inducible expression of anthranilate synthase in Catharanthus roseus hairy
roots, Biotechnology and Bioengineering, 102:1521-5 (2009).
Portle, S.,
Iadevaia1, S., San, K.-Y., Bennett, G.N., Mantzaris,
N., Environmentally-modulated changes in fluorescence distribution in cells
with oscillatory network dynamics, J Biotechnology, 140(3-4):203-17.
(2009).
Chung,
I.-M., Ali, M., Ahmad, A., Lee,O-K.
Kim, J-H., Yoon, D-Y., Peebles, C.A.M., and San, K.-Y., Flavonoid
Glucosides from the Hairy Roots of Catharanthus roseus, J Natural Products, 72(4):613-20 (2009).
Binder,
B.Y.K., Peebles, C.A.M., Shanks, J.V., and San, K.-Y., The effects of UV-B
stress on the production of terpenoid indole alkaloids
in Catharanthus roseus
hairy roots, Biotechnology Progress, 25:861-865 (2009).
Peebles,
C.A.M., Shanks, J.V., and San, K.-Y., The role of the octadecanoid
pathway in the production of terpenoid indole
alkaloids in Catharanthus roseus
hairy roots under normal and UV-B stress conditions, Biotechnology and
Bioengineering, 103(6):1248-54 (2009).
Martinez,
I., Zhu, J., Lin, H., Bennett, G.N., San, K.-Y., Replacing Escherichia coli
NAD-dependent glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with a NADP-dependent
enzyme from Clostridium acetobutylicum
facilitates NADPH dependent pathways, Metabolic Engineering, 10(6):352-359
(2008).
Chung, I.
M., Ali, M., Chun, S. C., San, K.-Y., Peebles, C. A. M., and Ahmad, A., New
catharanthusopimaranoside A And B from hairy root
cultures of Catharanthus roseus,
Chemistry of Natural Compounds, 44(4):458-462 (2008).
Wong,
M.S., Causey, T.B., Bennett, G.N., and San, K.-Y., Engineering
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Copolymer Composition in E.
coli, Biotechnology and Bioengineering, 99(4):919-28 (2008).
Singh, R.,
Vadlani, P.V., Harrison, M. L., Bennett, G.N.,
San, K.-Y., Aerobic production of isoamyl acetate
by overexpression of the yeast alcohol acetyl-transferase AFT1 and AFT2 in
Escherichia coli and using low-cost fermentation ingredients, Bioprocess
and Biosystems Engineering, 31:299-306 (2008).
Wong,
M.S., Causey, T.B., Bennett, G.N., and San, K.-Y., Reduction of acetate
accumulation in Escherichia coli cultures for increased recombinant protein
production, Metabolic Engineering, 10(2):97-108 (2008).
Peebles,
C.A.M., Gibson, S.I., Shanks, J.V., and San, K.-Y., A study on the
long-term maintenance of a transgenic Catharanthus
roseus hairy root line, Biotech. Progress,
23(6):1517-1518 (2007).
Peebles, C.A.M.,
Gibson, S.I., Shanks, J.V., and San, K.-Y., Characterization of an ethanol
inducible promoter system in Catharanthus roseus hairy roots, 23:1258-1260 (2007).
Chung
I.-M., Ali, M., Chun, S.-C., San, K.-Y., Peebles, C.A.M., and Ahmad, A.,
New Catharanthusopimaranoside A and B from
Cultures Hairy Roots of Catharanthus roseus, Chinese Journal of Chemistry, 25:1695-1699
(2007).
Chung
I.-M., Ali, M., Yang, Y.-M., Peebles, C.A.M., Chun, S.-C., Lee, S.-J., San,
K. Y. and Ahmad, A., Identification of New Compounds from Catharanthus roseus Hairy
Root Cultures, Bull. Korean Chem. Soc., 28:1294-1298 (2007).
Park Y.C.,
Yun N.R., San K.-Y., and Bennett G.N., Characterization of alcohol
dehydrogenase 1 and 3 from Neurospora crassa FGSC2489, Appl Microbiol Biotechnol. 76(2):349-56 (2007).
Chung,
I.-M., Hong, S.-B., Peebles, C.A.M., and San, K.-Y., Effect of the
engineered indole pathway on accumulation of phenolic compounds in Catharanthus roseus hairy
roots, Biotechnology Progress, 23:327-32 (2007).
Zhu, J., Shalel Levanon, S., Bennett,
G. N., and San, K.-Y., The YfiD protein
contributes to the pyruvate formate-lyase flux in
an E. coli arcA mutant strain, Biotechnology and
Bioengineering, 97:138-43 (2007). [Supplemental
Data]
Chung,
I.-M., H.-Y. Park, M. Ali, K.-Y. San, C.A.M Peebles, S.-B. Hong, and A.
Ahmad, A new chemical constituent from the hairy root cultures of Catharanthus roseus, Bull.
Korean Chem. Soc. 28(2):229-234 (2007).
Portle, S., Causey,
T. B., Wolf, K., Bennett, G. N., San, K.-Y., and Mantzaris,
N. V., Cell population heterogeneity in expression of a gene-switching
network with fluorescent markers of different half-lives, 128(2):362-75
(2007).
Bennett,
G. N.; San, K.-Y.,Enzyme
and co-factor engineering and their applications in the pharmaceutical and
fermentation industries. Fermentation Microbiology and Biotechnology (2nd
Edition), 217-248 (2007).
Peebles
C.M., Hong, S.-B., Gibson, S. I. And Shanks, J V., San, K.-Y., The effect
of terpenoid precursor feeding on Catharanthus roseus hairy
root over-expressing the alpha or the alpha and beta subunits of
anthranilate synthase, Biotechnology and Bioengineering, 93(3):534-40
(2006).
Sanchez,
A. M., Andrew J., Hussein I., Bennett, G. N., and San, K.-Y., Effect of
overexpression of a soluble pyridine nucleotide transhydrogenase (UdhA) on the production of poly(3-hydroxybutyrate) in
Escherichia coli, Biotechnology Progress, 22(2):420-5 (2006).
Sanchez,
A. M., Bennett, G. N., and San, K.-Y., Batch culture characterization and
metabolic flux analysis of succinate producing Escherichia coli strains,
Metabolic Engineering, 8:209-226 (2006).
Singh, R.,
Yang, Y.-T., Liu, Y., B., Bennett, G. N., and San, K.-Y., Expression of the
pfl gene and resulting metabolite flux
distribution in nuo and ackA-pta
E. coli mutant strains, Biotechnology Progress, 22(3):898-902 (2006).
Lin, H.,
Castro, N.M., Bennett, G. N., and San, K.-Y., Acetyl-CoA synthetase overexpression in Escherichia coli
demonstrates more efficient acetate assimilation and lower acetate
accumulation: a potential tool in metabolic engineering, Applied
Microbiology and Biotechnology, 71(6):870-4. (2006).
Peercy B.E.,
Cox, S.J, Shalel-Levanon, S., San, K.-Y.,
Bennett, G.N., A Kinetic Model of Oxygen's Regulation of Cytochrome Oxidase
bo3 and Cytochrome Oxidase bd through the
Sensor/Regulators FNR and Two Component ArcAB in
Escherichia coli, Journal of Theoretical Biology, 242(3):547-63 (2006).
Zhu, J., Shalel Levanon, S., Bennett,
G. N., and San, K.-Y., Effect of the global redox sensing/regulation
networks on Escherichia coli and metabolic flux distribution based on C-13
labeling experiments, Metabolic Engineering, 8:619-27 (2006).
Park Y.C.,
Yun N.R., San K.-Y., Bennett G.N., Molecular cloning and characterization
of the alcohol dehydrogenase ADH1 gene of Candida utilis
ATCC 9950. J Ind Microbiol
Biotechnol. 33:1032-6 (2006).
Cox, S.J.,
Shalel Levanon, S.,
Sanchez, A., Lin, H., Peercy, B., Bennett, G.N.,
and San, K.-Y., Development of a metabolic network design and optimization
framework incorporating implementation constraints: a succinate production
case study, Metabolic Engineering, 8:46-57 (2006).
Hong,
S.-B., Peebles C.M., Shanks, J V., San, K.-Y., and Gibson, S. I., Terpenoid Indole Alkaloid Production by Catharanthus roseus Hairy
Roots induced by Agrobacterium tumefaciens
harboring rol ABC genes, Biotechnology and
Bioengineering, 93(2):386-90. (2006).
Hong,
S.-B., Peebles C.M., Shanks, J V., San, K.-Y., and Gibson, S. I.,
Expression of the arabidopsis
feedback-insensitive anthranilate synthase holoenzyme and tryptophan
decarboxylase genes in Catharanthus roseus hairy roots, Journal of Biotechnology, 122:28-38
(2006).
Lin, H.,
Bennett, G. N., and San, K.-Y., Genetic reconstruction of the aerobic
central metabolism in Escherichia coli for the absolute aerobic production
of succinate, Biotechnology and Bioengineering, 89: 148-156 (2005).
Shalel Levanon, S., San, K.-Y., and Bennett, G. N., Effect of
Oxygen on the E. coli ArcA and FNR Regulation Systems
and Metabolic Responses, Biotechnology and Bioengineering, 89:556-64
(2005).
Lin, H.,
Bennett, G. N., and San, K.-Y., Metabolic engineering of aerobic succinate
production systems in Escherichia coli to improve process productivity and
achieve the maximum theoretical succinate yield, Metabolic Engineering,
7:116-127 (2005).
Dittrich, C.
R., Vadali, R.V. Bennett, G. N., and San, K.-Y.,
Redistribution of metabolic fluxes in the central aerobic metabolic pathway
of E. coli mutant strains with deletion of the ackA-pta
and poxB pathways for the synthesis of isoamyl acetate, Biotechnology Progress, 21, 627-631
(2005).
Dittrich,
C.R., San, K.-Y., and Bennett, G.N., Cofactors in metabolic engineering of
ester production, Proceedings of the American Chemical Society Symposium on
Genetic Engineering in Flavor Chemistry: Applications and Potentials, ACS
Press, in press (2005).
Sanchez,
A. M., Bennett, G. N., and San, K.-Y., Efficient succinate production from
glucose through overexpression of pyruvate carboxylase in an Escherichia
coli alcohol dehydrogenase and lactate dehydrogenase mutant, Biotechnology
Progress, 21, 358-365 (2005).
Lin, H.,
Bennett, G. N., and San, K.-Y., Effect of carbon sources differing in
oxidation state and transport route on succinate production in
metabolically engineered Escherichia coli, Journal of Industrial
Microbiology & Biotechnology, 32(3):87-93 (2005).
Sanchez,
A. M., Bennett, G. N., and San, K.-Y., Novel pathway engineering design of
the anaerobic central metabolic pathway in Escherichia coli to increase
succinate yield and productivity, Metabolic Engineering, 7(3):229-239
(2005).
Sanchez,
A. M., Bennett, G. N., and San, K.-Y., Effect of Different Levels of NADH
Availability on Metabolic Fluxes of Escherichia coli Chemostat
Cultures in Defined Medium, Journal of Biotechnology, 117(4):395-405
(2005).
Lin, H.,
Bennett, G. N., and San, K.-Y., Effect of Sorghum vulgare phosphoenolypyruvate carboxylase and Lactococcus lactis pyruvate
carboxylase coexpression on succinate production
in mutant strains of Escherichia coli, Applied Microbiology and
Biotechnology, 67(4):515-23 (2005).
San,
K.-Y., Integration of undergraduate research in the BIOE curriculum at Rice
University, 2005 ASEE Annual Conference Proceedings (2005).
Lin, H.,
Bennett, G. N., and San, K.-Y., Fed batch culture of a metabolically
engineered Escherichia coli strain designed for high level succinate
production and yield under aerobic conditions, Biotechnology and
Bioengineering, 90:775-9 (2005).
Dittrich, C.
R., Vadali, R.V. Bennett, G. N., and San, K.-Y.,
Characterization of the acetate-producing pathways in Escherichia coli,
Biotechnology Progress, 21(4):1062-7 (2005).
Vadali, R.V.,
Fu, Y., Bennett, G. N., San, K. Y., Enhanced lycopene productivity by manipulation
of carbon flow to isopentenyl diphosphate in Escherichia coli,
Biotechnology Progress, 21:1558-1561 (2005).
Peebles
C.M., Hong, S.-B., Gibson, S. I. And Shanks, J V., San, K.-Y., The
transient effects of over-expressing anthranilate synthase alpha and beta
subunits in Catharanthus roseus
hairy root, Biotechnology Progress, 21:1572-1576 (2005).
Shalel Levanon, S., San, K.-Y., and Bennett, G. N., Effect of ArcA and FNR on the expression of genes related to the
oxygen regulation and the glycolysis pathway in Escherichia coli under
microaerobic growth conditions, Biotechnology and Bioengineering,
92(2):147-59 (2005).
Yun,
N.-R., San, K.-Y., and Bennett, G.N., Effect of inactivation of adhE or pta-ackA in NADH
dehydrogenase-deficient Escherichia coli on the pattern of anaerobic
metabolic products, Journal of Applied Microbiology, 99:1404-1412 (2005).
Lin, H.,
Bennett, G. N., and San, K.-Y., Chemostat culture
characterization of Escherichia coli mutant strains metabolically
engineered for aerobic succinate production: a study of the modified
metabolic network based on metabolite profile, enzyme activity and gene
expression profile, Metabolic Engineering, 7: 337-352 (2005).
Shalel Levanon, S., San, K.-Y., and Bennett, G. N., Effect of
Oxygen, and ArcA and FNR Regulators on the
Expression of Genes Related to the Electron Transfer Chain and the TCA
Cycle in Escherichia coli, Metabolic Engineering, 7:364-374 (2005).
Berrios-Rivera,
S. J., Sanchez, A. M., Bennett, G. N., San, K. Y., Effect of different
levels of NADH availability on metabolite distribution in Escherichia
coli on minimal and complex media, Applied Microbiology and
Biotechnology, 65(4): 426-432(2004). .
San, K.-Y.
and Bennett, G.N., Expression Systems for DNA
Processes, in the Encyclopedia of Molecular Cell Biology And Molecular
Medicine, Meyers, R.A. (ed.), VCH, New York, Vol. 4, 355-377 (2004).
Vadali, R.V.,
Horton, C.E., Rudolph, F.B., Bennett, G. N., San, K. Y., Production of isoamyl acetate in ackA-pta
and/or ldh mutants of Escherichia coli,
Applied Microbiology and Biotechnology, 63:698-704 (2004).
Vadali, R.V.,
Bennett, G. N., San, K. Y., Cofactor engineering of CoA/acetyl-CoA and its
effect on metabolic flux redistribution in Escherichia coli,
Metabolic Engineering, 6, 133-139 (2004).
Vadali, R.V.,
Bennett, G. N., San, K. Y., Applicability of CoA/acetyl-CoA manipulation
system to enhance isoamyl acetate production in Escherichia
coli, Metabolic Engineering, 6:294-299 (2004).
Hughes, E.
H., Hong, S.-B., Gibson, S. I., Shanks, J. V., San, K.-Y., Expression of a
Feedback-Resistant Anthranilate Synthase in Catharanthus
roseus Hairy Roots Provides Evidence for
Tight Regulation of Terpenoid Indole Alkaloid
Levels, Biotechnology and Bioengineering, 86:718-727 (2004).
Vadali, R.V.,
Bennett, G. N., San, K. Y., Enhanced Isoamyl
acetate production upon manipulation of the acetyl-CoA node in Escherichia
coli, Biotechnology Progress, 20(3):692-7 (2004).
Hughes, E.
H., Hong, S.-B., Gibson, S. I., Shanks, J. V., San, K.-Y., Metabolic
Engineering of the Indole Pathway in Catharanthus
roseus Hairy Roots and Increased
Accumulation of Tryptamine and Serpentine, Metabolic Engineering, 6:268-276
(2004).
Berrios-Rivera,
S. J., San, K.-Y., and Bennett, G. N., The Effect of Carbon Sources and
Lactate Dehydrogenase Deletion on 1,2-Propanediol Production in Escherichia
coli, Journal of Industrial Microbiology and Biotechnology, 30:
34-40 (2003).
Hong,
S.-B., Hughes, E.H., Shanks, J.V., San, K.-Y., and Gibson, S. I., *Role of the
Non-Mevalonate Pathway in Indole Alkaloid Production by Catharanthus
roseus Hairy Roots, Biotechnology
Progress, 19: 1105-1108 (2003).
Berrios-Rivera,
S. J., San, K.-Y., and Bennett, G. N., The Effect of Carbon Sources and
Lactate Dehydrogenase Deletion on 1,2-Propanediol Production in Escherichia
coli, Journal of Industrial Microbiology and Biotechnology, in press
(2002).
Hughes, E.
H., Hong, S.-B., Shanks, J. V., San, K.-Y., Gibson, S. I., Characterization
of an Inducible Promoter System in Catharanthus
roseus Hairy Roots, Biotechnology
Progress, in press (2002).
San, K.-Y.
, A. Saterbak, and L. V. McIntire, A New Cellular
and Molecular Engineering Curriculum at Rice University to be presented at
the 2002 ASEE Annual Conference, Montreal, Quebec Canada, June 15-19, 2002.
Berrios
-Rivera, S. J., Bennett, G. N., and San, K.-Y. San, Metabolic Engineering
of Escherichia coli through Genetic Manipulation of NADH
Availability, Metabolic Engineering, 4: 217-229 (2002).
Berrios-Rivera,
S. J., Bennett, G. N., and San, K.-Y., The Effect of Manipulating NADH
Availability on the Redistribution of Metabolic Fluxes in Escherichia
coli Chemostat Cultures, Metabolic
Engineering, 4: 230-237 (2002).
Berrios-Rivera,
S. J., San, K.-Y., and Bennett, G. N., The Effect of Anprtase
Overexpression on the Total Levels Of NAD, the NADH/NAD+ Ratio, and the
Distribution of Metabolites in Escherichia coli, Metabolic
Engineering, 4: 238-247 (2002).
San,
K.-Y., Bennett, G.N., Berrios-Rivera, S.J., Vadali,
R.V., Yang, Y.-T., Horton, E., Rudolph, F.B., Berna Sariyar,
B., Backwood, K., Metabolic Engineering through
Cofactor Manipulation and Its Effects on Metabolic Flux Redistribution in Escherichia
coli, Metabolic Engineering, 4:182-192 (2002).
Wardwell,
S.A., Yang, Y.-T., Chang H.-Y., San, K.-Y., Rudolph, F.B., Bennett, G.N.,
Expression of the Klebsiella pneumoniae CG21
Acetoin Reductase Gene in Clostridium acetobutylicum
ATCC 824, J Ind Microbiol
Biotechnol, 27:220-7 (2001).
Saterbak, A.,
San, K.-Y. and McIntire, L.V., Development of a Novel
Foundation Course for Biomedical Engineering Curriculum, ASEE Annual
Conference Proceedings (2001).
Yang,
Y.-T, Bennett, G. N., and San, K.-Y., The Effects of Feed and Intracellular
Pyruvate Levels on the Metabolic Fluxes Redistribution in Escherichia
coli with Fermentative Lactate Dehydrogenase Overexpression,
Metabolic Engineering, 3:115-123 (2001).
Bennett,
G.N. and San, K.-Y., Microbial Formation, Biotechnological Production and
Applications of 1,2-Propanediol, App. Micro. Biotech., 55:1-9 (2001).
Yang,
Y.-T, Peredelchuk, M., Bennett, G. N., and San,
K.-Y., The Effect of Variation of Klebsiella
pneumoniae Acetolactate Synthase Expression on
Metabolic Fluxes Redistribution in Escherichia coli,
Biotechnology and Bioengineering, 69:150-159 (2000).
Susana J.
Berrios-Rivera, Yang, Y.-T., Bennett, G. N., San, K.-Y., Effect of Glucose
Analog Supplementation on Metabolic Flux Distribution in Anaerobic Chemostat Cultures of Escherichia coli
Metabolic Engineering, 2:149-154 (2000).
Yang,
Y.-T, Bennett, G. N., and San, K.-Y., The Interactions of nuo and ack/pta Mutations on Metabolic Flux Redistribution in Escherichia
coli, Biotechnology and Bioengineering, 65:291-297 (1999).
Yang,
Y.-T, Bennett, G. N., and San, K.-Y., Redistribution of Metabolic Fluxes in
Escherichia coli with Fermentative Lactate Dehydrogenase
Overexpression and Deletion, Metabolic Engineering, 1:141-152 (1999).
Aristidou,
A.A., Bennett, G. N., and San, K.-Y., Metabolic Flux Analysis of Escherichia
coli Expressing the Bacillus subtilis Acetolactate
Synthase in Batch and Continuous Cultures, Biotechnology and
Bioengineering, 63:737-749 (1999).
Aristidou,
A.A., Bennett, G. N., and San, K.-Y., Improvement of Biomass Yield and
Recombinant Gene Expression in Escherichia coli by Using Fructose as
the Primary Carbon Source, Biotechnology Progress, 15(1)140-145 (1999).
Yang,
Y.-T., Bennett, G. N., and San, K.-Y., Metabolic Flux Analysis of E. coli
Deficient in the Acetate Production Pathway and Expressing the B.
subtilis Acetolactate Synthase, Metabolic Engineering,
1: 26-34 (1999).
Yang,
Y.-T., Bennett, G. N., and San, K.-Y., Genetic and Metabolic Engineering,
Electronic Journal of Biotechnology, Vol 1(3) (1998).
Liu, C.
H., Niranjan, S. C., Clark, J. W. Jr., San, K.
Y., Zwischenberger, J. B. and Bidani,
A., Airway Mechanics, Gas Exchange and Blood Flow in a Nonlinear Model of
the Human Lung, J Appl Physiol
(HEG), 84 (4): 1447-69 (1998).
Berrios-Rivera,
S. J., Yang, Y.-T., San, K.-Y. and G. N. Bennett, Effect of Glucose Analog
Supplementation in Anaerobic Chemostat Cultures
of Escherichia coli, Proc. XVIII Interamerican
Congress of Chemical Engineering, San Juan, Puerto Rico, December (1998).
Chou,
C,-H., Bennett, G.N. and San, K.-Y., Genetic Manipulation of
Stationary-Phase Genes to Enhance Recombinant Protein in Escherichia
coli, Biotech. Bioeng., 50:636-642 (1996).
San, K.-Y.
and Bennett, G.N., Expressions Systems for DNA
Processes, in the Encyclopedia of Molecular Biology: Fundamentals and
Applications, Meyers, R.A. (ed.), VCH, New York., p.271-278 (1996).
Chou, C.
H., Aristidou, A. A., Meng,
S.Y., Bennett, G.N., and San, K.-Y., Characterization of a pH-Inducible
Promoter System for High Level Expression of Recombinant Proteins in
Escherichia coli, Biotech. Bioeng., 47:186-192 (1995).
Aristidou, A.
A., Bennett, G.N., and San, K.-Y., Metabolic Engineering of Escherichia
coli to Enhance Recombinant Protein Production through Acetate
Reduction, Biotechnology Progress, 11:475-478 (1995).
San, K.-Y.
and Bennett, G.N., Expressions Systems for DNA Processes, in the
Encyclopedia of Molecular Biology and Biotechnology, Meyers, R.A. (ed.),
VCH, New York, p. 306-310 (1995).
Chou,
C.-H., Bennett, G. N. and San, K.-Y., Effect of Modulated Glucose Uptake on
High-Level Recombinant Protein Production in a dense Escherichia coli
Dense Culture, Biotechnology Progress, 10:644-647 (1994).
Niranjan,
S.C., Clark, J.W., San, K.-Y., Zwischenberger,
J.B., and Bidani, A., Mathematical Analysis of
Gas Exchange in an Intravascular Blood Gas Exchanger (IVOX), J. Applied
Physiology, 77(4):1716-1730 (1994).
Niranjan,
S.C., Clark, J.W. , San, K.-Y., Zwischenberger,
J.B., and Bidani, A., Simulation of Gas Transport
in an Intravenacaval Blood-Gas Exchanger Device
(IVOX), Proc. International Federation of Automatic Control Symposium on
Modeling and Control in Biomedical Systems, Galveston, Tx.,
pp.198-201 (1994).
Liu, C.H.,
Niranjan, S. C., Clark, J.W., San, K.-Y. San, and
Bidani, A., Analysis of Airway Mechanisms in a
Ventilated Lumped Alveolar Model Coupled with Pulmonary Gas Exchange, Proc.
International Federation of Automatic Control Symposium on Modeling and
Control in Biomedical Systems, Galveston, TX., pp527-530 (1994).
Chou,
C.-H., Bennett, G. N. and San, K.-Y., Effect of Modified Glucose Uptake
using Genetic Engineering Techniques on High-Level Recombinant Protein
Production in Escherichia coli Dense Cultures, Biotech. Bioeng.,
44:952-960 (1994).
Aristidou, A.
A., San, K.-Y., and Bennett, G.N., Modification of Central Metabolic
Pathway in Escherichia coli to Reduce Acetate Accumulation by
Heterologous Expression of the Bacillus subtilis Acetolactate
Synthase Gene, Biotech. Bioeng., 44:944-951 (1994).
San,
K.-Y., G. N. Bennett, Aristidou, A.A., C-H Chou,
A.A., Strategies in High Level Expression of Recombinant Protein in Escherichia
coli, Annals of the New York Academy of Sciences, Vol 721, 257-267
(1994).
San,
K.-Y., G. N. Bennett, C-H Chou, and Aristidou,
A.A., An Optimization Study of a pH-Inducible Promoter System for High
Level Recombinant Protein Production in Escherichia coli, Annals of
the New York Academy of Sciences, Vol 721, 268-277 (1994).
Yu, P.,
and San, K.-Y., Continuous Production of Cell-Free Recombinant Proteins
Using Escherichia coli, Biotechnology Progress, 9:587-593 (1993).
Aristidou, A.
A., Yu, P., and San, K. -Y., Effects of Glycine Supplement on Enzyme
Production and Release in Recombinant Escherichia coli,
Biotechnology Letters, 15, 331-336 (1993).
Pollard,
J.F., Broussard, M.R., Garrison, D.B., and San, K.-Y., Process Identification
using Neural Networks, Computers in Chemical Engineering, 16:253-270
(1992).
Tolentino,
G.J., Meng, S.Y., Bennett, G.N., and San, K.-Y.,
A pH-Regulated Promoter for the Expression of Recombinant Proteins in Escherichia
coli, Biotechnol. Lett. 14:157-162 (1992).
Yu, P.,
and San, K. -Y., Protein Release in Recombinant Escherichia coli
Using Bacteriocin Release Protein, Biotechnology
Progress, 8, 25-29 (1991).
Yu, P., Aristidou, A. A., and San, K.-Y., Synergistic Effect of
Glycine and Bacteriocin Release Protein in the
Release of Periplasmic Protein in Recombinant E. coli, Biotechnology
Letters, 13 (5), 311-316 (1991).
Weber,
A.E., Yu, E., and San, K.-Y., The Effect of the Partition Locus on Plasmid
Stability and Expression of a Prolonged Chemostat
Culture, J. of Biotechnology, 18, 141-152 (1991).
Weber,
A.E. and San, K.-Y., Population Dynamics of a Recombinant Culture in a Chemostat under Prolonged Cultivation, Biotech. Bioeng.,
36, 727-736 (1990).
Cardello,
R.J. and K.-Y. San, Process Analysis and Identification with a Real Time
Intelligent Bioreactor Supervisory Controller, Automatic Control
Conference, pp. 2167-2172, San Diego, Ca, (1990).
San,
K.-Y., and McIntire, L.V., A Program on Biochemical and Biomedical
Engineering, Chemical Engineering Education, 23, 200-203 (1989).
Cardello,
R.J. and San K.-Y., Design and Real-Time Implementation of an Intelligent
Bioreactor Control System, Proc. 1989 Automatic Control Conference,
Pittsburgh, PA, 2411-2417 (1989).
Weber,
A.E. and San, K.-Y., A Comparison of Two Plating Techniques to Estimate
Plasmid Stability of a Prolonged Chemostat
Culture, Biotechnol. Techniques, 3, 397-400 (1989).
Weber,
A.E. and San, K.-Y., Dynamics of Plasmid Maintenance in a CSTR upon
Square-Wave Perturbations in the Dilution Rate, Biotech. Bioeng.,
34, 1104-1113 (1989).
Niranjan,
S.C. and K.-Y. San, Analysis of a Framework Using Material Balances in
Metabolic Pathways to Elucidate Cellular Metabolism, Biotech. Bioeng.,
34, 496-501 (1989).
San, K.-Y.
and Stephanopoulos, G., Optimization of Fed-batch
Penicillin Fermentation. A Case of Optimal Control of Singular Sys-tems with State Constraints, Biotech. Bioeng.,
34, 72-78 (1989).
San, K.-Y.
and Weber, A.E., Data Analysis of Plasmid
Maintenance in a CSTR, Biotech. Bioeng., 33, 451-459 (1989).
Weber,
A.E. and San, K.-Y., Enhanced Plasmid Maintenance in a CSTR upon
Square-Wave Perturbations in the Dilution Rate, Biotechnol. Lett., 10, 531-536 (1988).
Niranjan,
S.C. and K.-Y. San, Optimal Feedback Control of a Bioreactor with a Remote
Sensor, Proc. 1988 Automatic Control Con-ference,
Atlanta, Georgia, 1106-1111 (1988).
San,
K.-Y., Papoutsakis, E.T., and Stephanopoulos,
G.N., Measurements, Data Analysis and Control, In Handbook on Anaerobic Fermenta-tions, Erickson, L.E. and Fung D. (Eds.).
Chapter 14, p. 441-462, Marcel Dekker Inc., New York (1988).
Cardello R.J.
and San, K.-Y., The Design of Controllers for Batch Bioreactors, Biotech. Bioeng.,
32, 519-526 (1988).
Tolentino
G.J. and San, K.-Y., Plasmid Maintenance and Gene Ex-pression
under Aerobic and Anaerobic Conditions Biotechnol. Lett.,
10, 373-376 (1988).
Niranjan,
S.C. and K.-Y. San, Optimal Feedback Control of a Bioreactor with a Remote
Sensor, Proc. 1988 Automatic Control Con-ference,
Atlanta, Georgia, 1106-1111 (1988).
Weber,
A.E. and San, K.-Y., Persistence and Expression of the Plasmid pBR322 in Escherichia
coli K12 Cultured in a Complex Medium, Biotechnol. Lett.,
9, 757-760 (1987).
Cardello R.J.
and San, K.-Y., Application of Gain Scheduling to the Control of Batch
Bioreactors, Proc. 1987 Automatic Control Conference, Minneapolis,
Minnesota, 682-686 (1987).
Weber A.E.
and San, K.-Y., Effects of Square-Wave Perturbations in Dilution Rate on
Plasmid Maintenance and Gene Expression, Bioprocess Engineering Colloquium,
ASME Winter Annual Meeting, Boston, Massachusetts, p. 75-78, Dean, R.C.,
Jr. and Nerem, R.M. (Eds)
(1987).
Cardello
R.J., Broussard M.R. and San, K.-Y., Development of an Expert System Based
Bioreactor Control Scheme, Bioprocess Engineering Colloquium, ASME Winter
Annual Meeting, Boston, Massachusetts, p. 21-24, Dean, R.C., Jr. and Nerem, R.M. (Eds) (1987).
San, K.-Y.
and Stephanopoulos, G.N., The Effect of Growth
Rate De-lays on the Optimal Profile of Fed-batch Reactors, Biotech. Bio-eng., 28, 356-361 (1986).
Davison,
B.H., San, K.-Y. and Stephanopoulos, G.N., Stable Compe-tition Coexistence in a Continuous Fermentor with Size-selective Proper-ties, Biotechnol.
Progress, 1, 260-269 (1985).
Stephanopoulos,
G.N., San, K.-Y. and Davison, B.H., A Novel Bioreactor-cell
Precipitator Combination for High-cell Density, High Flow Continuous
Fermentations, Biotechnol. Progress, 1, 250-259 (1985).
San, K.-Y.
and Stephanopoulos, G.N., A Note on the Optimality
Cri-teria for Maximum Biomass Production in a
Fed-Batch Reactor, Biotech. Bioeng., 26, 1261-1264 (1984).
San, K.-Y.
and Stephanopoulos, G.N., Studies on On-line Bioreactor Identification,
Part IV - Utilization of pH Measurements for Product Estimation, Biotech. Bioeng.,
26, 1209-1218 (1984).
Grosz, R.,
Stephanopoulos, G.N. and San, K.-Y., Studies on On-line Bioreactor
Identification, Part III - Sensitivity Problems with Res-piration Quotient and Heat Evolution Measurements,
Biotech. Bioeng., 26, 1198-1208 (1984).
San, K.-Y.
and Stephanopoulos, G.N., Studies on On-line
Bioreactor Identification, Part II - Numerical and Experimental Results,
Biotech. Bioeng., 26, 1189-1197 (1984).
Stephanopoulos,
G.N. and San, K.-Y., Studies on On-line Bioreactor Identification, Part I -
Theory, Biotech. Bioeng., 26, 1176-1188 (1984).
Stephanopoulos,
G.N. and San, K.-Y., On the Continuous Monitoring of Time Varying
Parameters, Proc. 1st IFAC Symp. on Biotechnical Processes, 195-199 (1983).
San, K.-Y.
and Stephanopoulos, G.N., Optimal Control Policy
for Substrate Inhibited Kinetics with Enzyme Deactivation in an Isothermal
CSTR, AIChE. J., 29, 417-424 (1983).
Stephanopoulos,
G.N. and San K.-Y., On-Line Estimation of the State of Biochemical
Reactors, Proc. of ISCRE-7, ACS Symposium Series 196, J. Wei and C.
Georgakis (eds.), 155-164 (1982).
Stephanopoulos,
G.N. and San K.-Y., State Estimation for Computer Control of Biochemical
Reactors, Proc. 6th Fermentation Symposium, July 15-20, 1981, London,
Canada, vol. 1, 399-407, M. Moo-Young, C.W. Robinson, C. Vezino (eds.)(1981).
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