Publications:

Textbook:

"Bioengineering Fundamentals" with Ann Saterbak and Larry V. McIntire (Prentice Hall, January 2007, ISBN-10: 0130938386). The textbook is intended for a sophomore level bioengineering introductory course. The book emphasizes on the quantitative treatment of conservation principles using biological systems as examples.

 

Patents and Patent Applications:

    1. Mutant E. coli Strain with Increased Succinic Acid Production, with Ailen Sánchez and George N. Bennett, U.S. Patent No. 7,223,567
    2. Aerobic Succinate Production in bacteria, with Henry Lin and George N. Bennett, U.S. Patent No. 7,244,610
    3. Recycling System for Manipulation of intracellular NADH Availability, with Susan J. Berrios-Rivera and George N. Bennett, U.S. Patent No. 7,256,016
    4. Aerobic Succinate Production in Bacteria, with Henry Lin and George N. Bennett, U.S. Patent No. 7,262,046
    5. Increasing Intracellular NADPH Availability in E. coli, with Ailen Sánchez and George N. Bennett, U.S. Patent No. 7,326,557
    6. Eight pending patent applications

 

Recent Articles

    1. Peebles, C.A.M., Hughes, E., Shanks, J.V., and San, K.-Y., “Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time”, Metabolic Engineering, accepted (2008).
    2. Martínez, I., Zhu, J., Lin, H., Bennett, G.N., San, K.-Y., " Replacing Escherichia coli NAD-dependent glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with a NADP-dependent enzyme from Clostridium acetobutylicum facilitates NADPH dependent pathways, Metabolic Engineering, in press (2008).
    3. Peebles, C.A.M., Sander, G.W., Li, M., Shanks, J.V., and San, K.-Y., “Five year maintenance of the inducible expression of anthranilate synthase in Catharanthus roseus hairy roots”, Biotechnology and Bioengineering, accepted (2008).
    4. Chung, I.-M., Ali, M., Chun, S.-C., Lee, S.-J., San, K.-Y., Peebles, C. A. M. and Ahmad, A., “New Sesquiterepene Glycosides from Cultures Hairy Roots of Catharanthus roseus”, Chemistry of Natural Compounds. Accepted (2008).
    5. Binder, B.Y.K., Peebles, C.A.M., Shanks, J.V., and San, K.-Y., “The effects of UV-B stress on the production of terpenoid indole alkaloids in Catharanthus roseus hairy roots”, Biotechnology Progress, in press (2008).
    6. Wong, M.S., Causey, T.B., Bennett, G.N., and San, K.-Y., “Engineering Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Copolymer Composition in E. coli”, Biotechnology and Bioengineering, 99(4):919-28 (2008).
    7. Singh, R., Vadlani, P.V., Harrison, M. L., Bennett, G.N., San, K.-Y., “Aerobic production of isoamyl acetate by overexpression of the yeast alcohol acetyl-transferase AFT1 and AFT2 in Escherichia coli and using low-cost fermentation ingredients”, Bioprocess and Biosystems Engineering, 31:299-306 (2008).
    8. Wong, M.S., Causey, T.B., Bennett, G.N., and San, K.-Y., “Reduction of acetate accumulation in Escherichia coli cultures for increased recombinant protein production”, Metabolic Engineering, 10(2):97-108 (2008).
    9. Peebles, C.A.M., Gibson, S.I., Shanks, J.V., and San, K.-Y., “A study on the long-term maintenance of a transgenic Catharanthus roseus hairy root line”, Biotech. Progress, 23(6):1517-1518 (2007).
    10. Peebles, C.A.M., Gibson, S.I., Shanks, J.V., and San, K.-Y., “Characterization of an ethanol inducible promoter system in Catharanthus roseus hairy roots”, 23:1258-1260 (2007).
    11. Chung I.-M., Ali, M., Chun, S.-C., San, K.-Y., Peebles, C.A.M., and Ahmad, A., “New Catharanthusopimaranoside A and B from Cultures Hairy Roots of Catharanthus roseus”, Chinese Journal of Chemistry, 25:1695 – 1699 (2007).
    12. Chung I.-M., Ali, M., Yang, Y.-M., Peebles, C.A.M., Chun, S.-C., Lee, S.-J., San, K. Y. and Ahmad, A., “Identification of New Compounds from Catharanthus roseus Hairy Root Cultures,” Bull. Korean Chem. Soc., 28:1294-1298 (2007).
    13. Park Y.C., Yun N.R., San K.-Y., and Bennett G.N., “Characterization of alcohol dehydrogenase 1 and 3 from Neurospora crassa FGSC2489”, Appl Microbiol Biotechnol. 76(2):349-56 (2007).
    14. Chung, I.-M., Hong, S.-B., Peebles, C.A.M., and San, K.-Y., “Effect of the engineered indole pathway on accumulation of phenolic compounds in Catharanthus roseus hairy roots”, Biotechnology Progress, 23:327-32 (2007).
    15. Zhu, J., Shalel Levanon, S., Bennett, G. N., and San, K.-Y., “The YfiD protein contributes to the pyruvate formate-lyase flux in an E. coli arcA mutant strain”, Biotechnology and Bioengineering, 97:138-43 (2007). [Supplemental Data]
    16. Chung, I.-M., H.-Y. Park, M. Ali, K.-Y. San, C.A.M Peebles, S.-B. Hong, and A. Ahmad, “A new chemical constituent from the hairy root cultures of Catharanthus roseus,” Bull. Korean Chem. Soc. 28(2):229-234 (2007).
    17. Portle, S., Causey, T. B., Wolf, K., Bennett, G. N., San, K.-Y., and Mantzaris, N. V., “Cell population heterogeneity in expression of a gene-switching network with fluorescent markers of different half-lives,” 128(2):362-75 (2007).
    18. Peebles C.M., Hong, S.-B., Gibson, S. I. And Shanks, J V., San, K.-Y., “The effect of terpenoid precursor feeding on Catharanthus roseus hairy root over-expressing the alpha or the alpha and beta subunits of anthranilate synthase”, Biotechnology and Bioengineering, 93(3):534-40 (2006).
    19. Sánchez, A. M., Andrew J., Hussein I., Bennett, G. N., and San, K.-Y., “Effect of overexpression of a soluble pyridine nucleotide transhydrogenase (UdhA) on the production of poly(3-hydroxybutyrate) in Escherichia coli”, Biotechnology Progress, 22(2):420-5 (2006).
    20. Sánchez, A. M., Bennett, G. N., and San, K.-Y., “Batch culture characterization and metabolic flux analysis of succinate producing Escherichia coli strains”, Metabolic Engineering, 8:209–226 (2006).
    21. Singh, R., Yang, Y.-T., Liu, Y., B., Bennett, G. N., and San, K.-Y., “Expression of the pfl gene and resulting metabolite flux distribution in nuo and ackA-pta E. coli mutant strains, Biotechnology Progress, 22(3):898-902 (2006).
    22. Lin, H., Castro, N.M., Bennett, G. N., and San, K.-Y., “Acetyl-CoA synthetase overexpression in Escherichia coli demonstrates more efficient acetate assimilation and lower acetate accumulation: a potential tool in metabolic engineering”, Applied Microbiology and Biotechnology, 71(6):870-4. (2006).
    23. Peercy B.E., Cox, S.J, Shalel-Levanon, S., San, K.-Y., Bennett, G.N., “A Kinetic Model of Oxygen's Regulation of Cytochrome Oxidase bo3 and Cytochrome Oxidase bd through the Sensor/Regulators FNR and Two Component ArcAB in Escherichia coli”, Journal of Theoretical Biology, 242(3):547-63 (2006).
    24. Zhu, J., Shalel Levanon, S., Bennett, G. N., and San, K.-Y., “Effect of the global redox sensing/regulation networks on Escherichia coli and metabolic flux distribution based on C-13 labeling experiments”, Metabolic Engineering, 8:619-27 (2006).
    25. Park Y.C., Yun N.R., San K.-Y., Bennett G.N., “Molecular cloning and characterization of the alcohol dehydrogenase ADH1 gene of Candida utilis ATCC 9950”. J Ind Microbiol Biotechnol. 33:1032-6 (2006).
    26. Cox, S.J., Shalel Levanon, S., Sánchez, A., Lin, H., Peercy, B., Bennett, G.N., and San, K.-Y., “Development of a metabolic network design and optimization framework incorporating implementation constraints: a succinate production case study”, Metabolic Engineering, 8:46–57 (2006).
    27. Hong, S.-B., Peebles C.M., Shanks, J V., San, K.-Y., and Gibson, S. I., “Terpenoid Indole Alkaloid Production by Catharanthus roseus Hairy Roots induced by Agrobacterium tumefaciens harboring rol ABC genes”, Biotechnology and Bioengineering, 93(2):386-90. (2006).
    28. Hong, S.-B., Peebles C.M., Shanks, J V., San, K.-Y., and Gibson, S. I., “Expression of the arabidopsis feedback-insensitive anthranilate synthase holoenzyme and tryptophan decarboxylase genes in Catharanthus roseus hairy roots”, Journal of Biotechnology, 122:28-38 (2006).
    29. Cox, S.J., Shalel Levanon, S., Bennett, G. N., and San, K.-Y., "Genetically constrained metabolic flux analysis" Metabolic Engineering, 7: 445–456 (2005).
    30. Lin, H., Bennett, G. N., and San, K.-Y., “Genetic reconstruction of the aerobic central metabolism in Escherichia coli for the absolute aerobic production of succinate”, Biotechnology and Bioengineering, 89: 148-156 (2005).
    31. Shalel Levanon, S., San, K.-Y., and Bennett, G. N., “Effect of Oxygen on the E. coli ArcA and FNR Regulation Systems and Metabolic Responses”, Biotechnology and Bioengineering, 89:556-64 (2005).
    32. Lin, H., Bennett, G. N., and San, K.-Y., “Metabolic engineering of aerobic succinate production systems in Escherichia coli to improve process productivity and achieve the maximum theoretical succinate yield”, Metabolic Engineering, 7:116-127 (2005).
    33. Dittrich, C. R., Vadali, R.V. Bennett, G. N., and San, K.-Y., “Redistribution of metabolic fluxes in the central aerobic metabolic pathway of E. coli mutant strains with deletion of the ackA-pta and poxB pathways for the synthesis of isoamyl acetate”, Biotechnology Progress, 21, 627-631 (2005).
    34. Dittrich, C.R., San, K.-Y., and Bennett, G.N., Cofactors in metabolic engineering of ester production, Proceedings of the American Chemical Society Symposium on Genetic Engineering in Flavor Chemistry: Applications and Potentials, ACS Press, in press (2005).
    35. Sánchez, A. M., Bennett, G. N., and San, K.-Y., “Efficient succinate production from glucose through overexpression of pyruvate carboxylase in an Escherichia coli alcohol dehydrogenase and lactate dehydrogenase mutant”, Biotechnology Progress, 21, 358-365 (2005).
    36. Lin, H., Bennett, G. N., and San, K.-Y., “Effect of carbon sources differing in oxidation state and transport route on succinate production in metabolically engineered Escherichia coli”, Journal of Industrial Microbiology & Biotechnology, 32(3):87-93 (2005).
    37. Sánchez, A. M., Bennett, G. N., and San, K.-Y., “Novel pathway engineering design of the anaerobic central metabolic pathway in Escherichia coli to increase succinate yield and productivity”, Metabolic Engineering, 7(3):229-239 (2005).
    38. Sánchez, A. M., Bennett, G. N., and San, K.-Y., “Effect of Different Levels of NADH Availability on Metabolic Fluxes of Escherichia coli Chemostat Cultures in Defined Medium”, Journal of Biotechnology, 117(4):395-405 (2005).
    39. Lin, H., Bennett, G. N., and San, K.-Y., “Effect of Sorghum vulgare phosphoenolypyruvate carboxylase and Lactococcus lactis pyruvate carboxylase coexpression on succinate production in mutant strains of Escherichia coli”, Applied Microbiology and Biotechnology, 67(4):515-23 (2005).
    40. San, K.-Y., “Integration of undergraduate research in the BIOE curriculum at Rice University”, 2005 ASEE Annual Conference Proceedings (2005).
    41. Lin, H., Bennett, G. N., and San, K.-Y., “Fed batch culture of a metabolically engineered Escherichia coli strain designed for high level succinate production and yield under aerobic conditions”, Biotechnology and Bioengineering, 90:775-9 (2005).
    42. Dittrich, C. R., Vadali, R.V. Bennett, G. N., and San, K.-Y., “Characterization of the acetate-producing pathways in Escherichia coli”, Biotechnology Progress, 21(4):1062-7 (2005).
    43. Vadali, R.V., Fu, Y., Bennett, G. N., San, K. Y., “Enhanced lycopene productivity by manipulation of carbon flow to isopentenyl diphosphate in Escherichia coli", Biotechnology Progress, 21:1558-1561 (2005).
    44. Peebles C.M., Hong, S.-B., Gibson, S. I. And Shanks, J V., San, K.-Y., “The transient effects of over-expressing anthranilate synthase a and ß subunits in Catharanthus roseus hairy root”, Biotechnology Progress, 21:1572-1576 (2005).
    45. Shalel Levanon, S., San, K.-Y., and Bennett, G. N., “Effect of ArcA and FNR on the expression of genes related to the oxygen regulation and the glycolysis pathway in Escherichia coli under microaerobic growth conditions”, Biotechnology and Bioengineering, 92(2):147-59 (2005).
    46. Yun, N.-R., San, K.-Y., and Bennett, G.N., “Effect of inactivation of adhE or pta-ackA in NADH dehydrogenase-deficient Escherichia coli on the pattern of anaerobic metabolic products”, Journal of Applied Microbiology, 99:1404–1412 (2005).
    47. Lin, H., Bennett, G. N., and San, K.-Y., “Chemostat culture characterization of Escherichia coli mutant strains metabolically engineered for aerobic succinate production: a study of the modified metabolic network based on metabolite profile, enzyme activity and gene expression profile”, Metabolic Engineering, 7: 337–352 (2005).
    48. Shalel Levanon, S., San, K.-Y., and Bennett, G. N., “Effect of Oxygen, and ArcA and FNR Regulators on the Expression of Genes Related to the Electron Transfer Chain and the TCA Cycle in Escherichia coli”, Metabolic Engineering, 7:364–374 (2005).
    49. Lin, H., Vadali, R.V., Bennett, G. N., and San, K.-Y., “Increasing the acetyl-CoA pool in the presence of overexpressed phosphoenolpyruvate carboxylase or pyruvate carboxylase enhances succinate production in Escherichia coli”, Biotechnology Progress, 20:1599-1604 (2004).
    50. Berríos-Rivera, S. J., Sánchez, A. M., Bennett, G. N., San, K. Y., “Effect of different levels of NADH availability on metabolite distribution in Escherichia coli on minimal and complex media”, Applied Microbiology and Biotechnology, 65(4): 426-432(2004). .
    51. San, K.-Y. and Bennett, G.N., “Expression Systems for DNA Processes”, in the Encyclopedia of Molecular Cell Biology And Molecular Medicine”, Meyers, R.A. (ed.), VCH, New York, Vol. 4, 355-377 (2004).
    52. Vadali, R.V., Horton, C.E., Rudolph, F.B., Bennett, G. N., San, K. Y., “Production of isoamyl acetate in ackA-pta and/or ldh mutants of Escherichia coli”, Applied Microbiology and Biotechnology, 63:698-704 (2004).
    53. Vadali, R.V., Bennett, G. N., San, K. Y., “Cofactor engineering of CoA/acetyl-CoA and its effect on metabolic flux redistribution in Escherichia coli”, Metabolic Engineering, 6, 133-139 (2004).
    54. Vadali, R.V., Bennett, G. N., San, K. Y., “Applicability of CoA/acetyl-CoA manipulation system to enhance isoamyl acetate production in Escherichia coli”, Metabolic Engineering, 6:294-299 (2004).
    55. Hughes, E. H., Hong, S.-B., Gibson, S. I., Shanks, J. V., San, K.-Y., “Expression of a Feedback-Resistant Anthranilate Synthase in Catharanthus roseus Hairy Roots Provides Evidence for Tight Regulation of Terpenoid Indole Alkaloid Levels”, Biotechnology and Bioengineering, 86:718-727 (2004).
    56. Vadali, R.V., Bennett, G. N., San, K. Y., “Enhanced Isoamyl acetate production upon manipulation of the acetyl-CoA node in Escherichia coli”, Biotechnology Progress, 20(3):692-7 (2004).
    57. Hughes, E. H., Hong, S.-B., Gibson, S. I., Shanks, J. V., San, K.-Y., “Metabolic Engineering of the Indole Pathway in Catharanthus roseus Hairy Roots and Increased Accumulation of Tryptamine and Serpentine”, Metabolic Engineering, 6:268-276 (2004).
    58. Berríos-Rivera, S. J., San, K.-Y., and Bennett, G. N., "The Effect of Carbon Sources and Lactate Dehydrogenase Deletion on 1,2-Propanediol Production in Escherichia coli”, Journal of Industrial Microbiology and Biotechnology, 30: 34-40 (2003).
    59. Hong, S.-B., Hughes, E.H., Shanks, J.V., San, K.-Y., and Gibson, S. I., *Role of the Non-Mevalonate Pathway in Indole Alkaloid Production by Catharanthus roseus Hairy Roots”, Biotechnology Progress, 19: 1105 – 1108 (2003).
    60. Berríos-Rivera, S. J., San, K.-Y., and Bennett, G. N., "The Effect of Carbon Sources and Lactate Dehydrogenase Deletion on 1,2-Propanediol Production in Escherichia coli”, Journal of Industrial Microbiology and Biotechnology, in press (2002).
    61. Hughes, E. H., Hong, S.-B., Shanks, J. V., San, K.-Y., Gibson, S. I., “Characterization of an Inducible Promoter System in Catharanthus roseus Hairy Roots”, Biotechnology Progress, in press (2002).
    62. Berríos-Rivera, S. J., Bennett, G. N., and San, K.-Y. San, “Metabolic Engineering of Escherichia coli through Genetic Manipulation of NADH Availability”, Metabolic Engineering, 4: 217-229 (2002).
    63. Berríos-Rivera, S. J., Bennett, G. N., and San, K.-Y., “The Effect of Manipulating NADH Availability on the Redistribution of Metabolic Fluxes in Escherichia coli Chemostat Cultures”, Metabolic Engineering, 4: 230-237 (2002).
    64. Berríos-Rivera, S. J., San, K.-Y., and Bennett, G. N., “The Effect of Anprtase Overexpression on the Total Levels Of NAD, the NADH/NAD+ Ratio, and the Distribution of Metabolites in Escherichia coli”, Metabolic Engineering, 4: 238-247 (2002).
    65. San, K.-Y., Bennett, G.N., Berríos-Rivera, S.J., Vadali, R.V., Yang, Y.-T., Horton, E., Rudolph, F.B., Berna Sariyar, B., Backwood, K., "Metabolic Engineering through Cofactor Manipulation and Its Effects on Metabolic Flux Redistribution in Escherichia coli”, Metabolic Engineering, 4:182-192 (2002).

 

Complete List

Journal Articles

    1. Peebles, C.A.M., Hughes, E., Shanks, J.V., and San, K.-Y., “Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time”, Metabolic Engineering, accepted (2008).
    2. Martínez, I., Zhu, J., Lin, H., Bennett, G.N., San, K.-Y., " Replacing Escherichia coli NAD-dependent glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with a NADP-dependent enzyme from Clostridium acetobutylicum facilitates NADPH dependent pathways, Metabolic Engineering, in press (2008).
    3. Peebles, C.A.M., Sander, G.W., Li, M., Shanks, J.V., and San, K.-Y., “Five year maintenance of the inducible expression of anthranilate synthase in Catharanthus roseus hairy roots”, Biotechnology and Bioengineering, accepted (2008).
    4. Chung, I.-M., Ali, M., Chun, S.-C., Lee, S.-J., San, K.-Y., Peebles, C. A. M. and Ahmad, A., “New Sesquiterepene Glycosides from Cultures Hairy Roots of Catharanthus roseus”, Chemistry of Natural Compounds. Accepted (2008).
    5. Binder, B.Y.K., Peebles, C.A.M., Shanks, J.V., and San, K.-Y., “The effects of UV-B stress on the production of terpenoid indole alkaloids in Catharanthus roseus hairy roots”, Biotechnology Progress, in press (2008).
    6. Wong, M.S., Causey, T.B., Bennett, G.N., and San, K.-Y., “Engineering Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Copolymer Composition in E. coli”, Biotechnology and Bioengineering, 99(4):919-28 (2008).
    7. Singh, R., Vadlani, P.V., Harrison, M. L., Bennett, G.N., San, K.-Y., “Aerobic production of isoamyl acetate by overexpression of the yeast alcohol acetyl-transferase AFT1 and AFT2 in Escherichia coli and using low-cost fermentation ingredients”, Bioprocess and Biosystems Engineering, 31:299-306 (2008).
    8. Wong, M.S., Causey, T.B., Bennett, G.N., and San, K.-Y., “Reduction of acetate accumulation in Escherichia coli cultures for increased recombinant protein production”, Metabolic Engineering, 10(2):97-108 (2008).
    9. Peebles, C.A.M., Gibson, S.I., Shanks, J.V., and San, K.-Y., “A study on the long-term maintenance of a transgenic Catharanthus roseus hairy root line”, Biotech. Progress, 23(6):1517-1518 (2007).
    10. Peebles, C.A.M., Gibson, S.I., Shanks, J.V., and San, K.-Y., “Characterization of an ethanol inducible promoter system in Catharanthus roseus hairy roots”, 23:1258-1260 (2007).
    11. Chung I.-M., Ali, M., Chun, S.-C., San, K.-Y., Peebles, C.A.M., and Ahmad, A., “New Catharanthusopimaranoside A and B from Cultures Hairy Roots of Catharanthus roseus”, Chinese Journal of Chemistry, 25:1695 – 1699 (2007).
    12. Chung I.-M., Ali, M., Yang, Y.-M., Peebles, C.A.M., Chun, S.-C., Lee, S.-J., San, K. Y. and Ahmad, A., “Identification of New Compounds from Catharanthus roseus Hairy Root Cultures,” Bull. Korean Chem. Soc., 28:1294-1298 (2007).
    13. Park Y.C., Yun N.R., San K.-Y., and Bennett G.N., “Characterization of alcohol dehydrogenase 1 and 3 from Neurospora crassa FGSC2489”, Appl Microbiol Biotechnol. 76(2):349-56 (2007).
    14. Chung, I.-M., Hong, S.-B., Peebles, C.A.M., and San, K.-Y., “Effect of the engineered indole pathway on accumulation of phenolic compounds in Catharanthus roseus hairy roots”, Biotechnology Progress, 23:327-32 (2007).
    15. Zhu, J., Shalel Levanon, S., Bennett, G. N., and San, K.-Y., “The YfiD protein contributes to the pyruvate formate-lyase flux in an E. coli arcA mutant strain”, Biotechnology and Bioengineering, 97:138-43 (2007). [Supplemental Data]
    16. Chung, I.-M., H.-Y. Park, M. Ali, K.-Y. San, C.A.M Peebles, S.-B. Hong, and A. Ahmad, “A new chemical constituent from the hairy root cultures of Catharanthus roseus,” Bull. Korean Chem. Soc. 28(2):229-234 (2007).
    17. Portle, S., Causey, T. B., Wolf, K., Bennett, G. N., San, K.-Y., and Mantzaris, N. V., “Cell population heterogeneity in expression of a gene-switching network with fluorescent markers of different half-lives,” 128(2):362-75 (2007).
    18. Peebles C.M., Hong, S.-B., Gibson, S. I. And Shanks, J V., San, K.-Y., “The effect of terpenoid precursor feeding on Catharanthus roseus hairy root over-expressing the alpha or the alpha and beta subunits of anthranilate synthase”, Biotechnology and Bioengineering, 93(3):534-40 (2006).
    19. Sánchez, A. M., Andrew J., Hussein I., Bennett, G. N., and San, K.-Y., “Effect of overexpression of a soluble pyridine nucleotide transhydrogenase (UdhA) on the production of poly(3-hydroxybutyrate) in Escherichia coli”, Biotechnology Progress, 22(2):420-5 (2006).
    20. Sánchez, A. M., Bennett, G. N., and San, K.-Y., “Batch culture characterization and metabolic flux analysis of succinate producing Escherichia coli strains”, Metabolic Engineering, 8:209–226 (2006).
    21. Singh, R., Yang, Y.-T., Liu, Y., B., Bennett, G. N., and San, K.-Y., “Expression of the pfl gene and resulting metabolite flux distribution in nuo and ackA-pta E. coli mutant strains, Biotechnology Progress, 22(3):898-902 (2006).
    22. Lin, H., Castro, N.M., Bennett, G. N., and San, K.-Y., “Acetyl-CoA synthetase overexpression in Escherichia coli demonstrates more efficient acetate assimilation and lower acetate accumulation: a potential tool in metabolic engineering”, Applied Microbiology and Biotechnology, 71(6):870-4. (2006).
    23. Peercy B.E., Cox, S.J, Shalel-Levanon, S., San, K.-Y., Bennett, G.N., “A Kinetic Model of Oxygen's Regulation of Cytochrome Oxidase bo3 and Cytochrome Oxidase bd through the Sensor/Regulators FNR and Two Component ArcAB in Escherichia coli”, Journal of Theoretical Biology, 242(3):547-63 (2006).
    24. Zhu, J., Shalel Levanon, S., Bennett, G. N., and San, K.-Y., “Effect of the global redox sensing/regulation networks on Escherichia coli and metabolic flux distribution based on C-13 labeling experiments”, Metabolic Engineering, 8:619-27 (2006).
    25. Park Y.C., Yun N.R., San K.-Y., Bennett G.N., “Molecular cloning and characterization of the alcohol dehydrogenase ADH1 gene of Candida utilis ATCC 9950”. J Ind Microbiol Biotechnol. 33:1032-6 (2006).
    26. Cox, S.J., Shalel Levanon, S., Sánchez, A., Lin, H., Peercy, B., Bennett, G.N., and San, K.-Y., “Development of a metabolic network design and optimization framework incorporating implementation constraints: a succinate production case study”, Metabolic Engineering, 8:46–57 (2006).
    27. Hong, S.-B., Peebles C.M., Shanks, J V., San, K.-Y., and Gibson, S. I., “Terpenoid Indole Alkaloid Production by Catharanthus roseus Hairy Roots induced by Agrobacterium tumefaciens harboring rol ABC genes”, Biotechnology and Bioengineering, 93(2):386-90. (2006).
    28. Hong, S.-B., Peebles C.M., Shanks, J V., San, K.-Y., and Gibson, S. I., “Expression of the arabidopsis feedback-insensitive anthranilate synthase holoenzyme and tryptophan decarboxylase genes in Catharanthus roseus hairy roots”, Journal of Biotechnology, 122:28-38 (2006).
    29. Lin, H., Bennett, G. N., and San, K.-Y., “Genetic reconstruction of the aerobic central metabolism in Escherichia coli for the absolute aerobic production of succinate”, Biotechnology and Bioengineering, 89: 148-156 (2005).
    30. Shalel Levanon, S., San, K.-Y., and Bennett, G. N., “Effect of Oxygen on the E. coli ArcA and FNR Regulation Systems and Metabolic Responses”, Biotechnology and Bioengineering, 89:556-64 (2005).
    31. Lin, H., Bennett, G. N., and San, K.-Y., “Metabolic engineering of aerobic succinate production systems in Escherichia coli to improve process productivity and achieve the maximum theoretical succinate yield”, Metabolic Engineering, 7:116-127 (2005).
    32. Dittrich, C. R., Vadali, R.V. Bennett, G. N., and San, K.-Y., “Redistribution of metabolic fluxes in the central aerobic metabolic pathway of E. coli mutant strains with deletion of the ackA-pta and poxB pathways for the synthesis of isoamyl acetate”, Biotechnology Progress, 21, 627-631 (2005).
    33. Dittrich, C.R., San, K.-Y., and Bennett, G.N., Cofactors in metabolic engineering of ester production, Proceedings of the American Chemical Society Symposium on Genetic Engineering in Flavor Chemistry: Applications and Potentials, ACS Press, in press (2005).
    34. Sánchez, A. M., Bennett, G. N., and San, K.-Y., “Efficient succinate production from glucose through overexpression of pyruvate carboxylase in an Escherichia coli alcohol dehydrogenase and lactate dehydrogenase mutant”, Biotechnology Progress, 21, 358-365 (2005).
    35. Lin, H., Bennett, G. N., and San, K.-Y., “Effect of carbon sources differing in oxidation state and transport route on succinate production in metabolically engineered Escherichia coli”, Journal of Industrial Microbiology & Biotechnology, 32(3):87-93 (2005).
    36. Sánchez, A. M., Bennett, G. N., and San, K.-Y., “Novel pathway engineering design of the anaerobic central metabolic pathway in Escherichia coli to increase succinate yield and productivity”, Metabolic Engineering, 7(3):229-239 (2005).
    37. Sánchez, A. M., Bennett, G. N., and San, K.-Y., “Effect of Different Levels of NADH Availability on Metabolic Fluxes of Escherichia coli Chemostat Cultures in Defined Medium”, Journal of Biotechnology, 117(4):395-405 (2005).
    38. Lin, H., Bennett, G. N., and San, K.-Y., “Effect of Sorghum vulgare phosphoenolypyruvate carboxylase and Lactococcus lactis pyruvate carboxylase coexpression on succinate production in mutant strains of Escherichia coli”, Applied Microbiology and Biotechnology, 67(4):515-23 (2005).
    39. San, K.-Y., “Integration of undergraduate research in the BIOE curriculum at Rice University”, 2005 ASEE Annual Conference Proceedings (2005).
    40. Lin, H., Bennett, G. N., and San, K.-Y., “Fed batch culture of a metabolically engineered Escherichia coli strain designed for high level succinate production and yield under aerobic conditions”, Biotechnology and Bioengineering, 90:775-9 (2005).
    41. Dittrich, C. R., Vadali, R.V. Bennett, G. N., and San, K.-Y., “Characterization of the acetate-producing pathways in Escherichia coli”, Biotechnology Progress, 21(4):1062-7 (2005).
    42. Vadali, R.V., Fu, Y., Bennett, G. N., San, K. Y., “Enhanced lycopene productivity by manipulation of carbon flow to isopentenyl diphosphate in Escherichia coli", Biotechnology Progress, 21:1558-1561 (2005).
    43. Peebles C.M., Hong, S.-B., Gibson, S. I. And Shanks, J V., San, K.-Y., “The transient effects of over-expressing anthranilate synthase a and ß subunits in Catharanthus roseus hairy root”, Biotechnology Progress, 21:1572-1576 (2005).
    44. Shalel Levanon, S., San, K.-Y., and Bennett, G. N., “Effect of ArcA and FNR on the expression of genes related to the oxygen regulation and the glycolysis pathway in Escherichia coli under microaerobic growth conditions”, Biotechnology and Bioengineering, 92(2):147-59 (2005).
    45. Yun, N.-R., San, K.-Y., and Bennett, G.N., “Effect of inactivation of adhE or pta-ackA in NADH dehydrogenase-deficient Escherichia coli on the pattern of anaerobic metabolic products”, Journal of Applied Microbiology, 99:1404–1412 (2005).
    46. Lin, H., Bennett, G. N., and San, K.-Y., “Chemostat culture characterization of Escherichia coli mutant strains metabolically engineered for aerobic succinate production: a study of the modified metabolic network based on metabolite profile, enzyme activity and gene expression profile”, Metabolic Engineering, 7: 337–352 (2005).
    47. Shalel Levanon, S., San, K.-Y., and Bennett, G. N., “Effect of Oxygen, and ArcA and FNR Regulators on the Expression of Genes Related to the Electron Transfer Chain and the TCA Cycle in Escherichia coli”, Metabolic Engineering, 7:364–374 (2005).
    48. Berríos-Rivera, S. J., Sánchez, A. M., Bennett, G. N., San, K. Y., “Effect of different levels of NADH availability on metabolite distribution in Escherichia coli on minimal and complex media”, Applied Microbiology and Biotechnology, 65(4): 426-432(2004). .
    49. San, K.-Y. and Bennett, G.N., “Expression Systems for DNA Processes”, in the Encyclopedia of Molecular Cell Biology And Molecular Medicine”, Meyers, R.A. (ed.), VCH, New York, Vol. 4, 355-377 (2004).
    50. Vadali, R.V., Horton, C.E., Rudolph, F.B., Bennett, G. N., San, K. Y., “Production of isoamyl acetate in ackA-pta and/or ldh mutants of Escherichia coli”, Applied Microbiology and Biotechnology, 63:698-704 (2004).
    51. Vadali, R.V., Bennett, G. N., San, K. Y., “Cofactor engineering of CoA/acetyl-CoA and its effect on metabolic flux redistribution in Escherichia coli”, Metabolic Engineering, 6, 133-139 (2004).
    52. Vadali, R.V., Bennett, G. N., San, K. Y., “Applicability of CoA/acetyl-CoA manipulation system to enhance isoamyl acetate production in Escherichia coli”, Metabolic Engineering, 6:294-299 (2004).
    53. Hughes, E. H., Hong, S.-B., Gibson, S. I., Shanks, J. V., San, K.-Y., “Expression of a Feedback-Resistant Anthranilate Synthase in Catharanthus roseus Hairy Roots Provides Evidence for Tight Regulation of Terpenoid Indole Alkaloid Levels”, Biotechnology and Bioengineering, 86:718-727 (2004).
    54. Vadali, R.V., Bennett, G. N., San, K. Y., “Enhanced Isoamyl acetate production upon manipulation of the acetyl-CoA node in Escherichia coli”, Biotechnology Progress, 20(3):692-7 (2004).
    55. Hughes, E. H., Hong, S.-B., Gibson, S. I., Shanks, J. V., San, K.-Y., “Metabolic Engineering of the Indole Pathway in Catharanthus roseus Hairy Roots and Increased Accumulation of Tryptamine and Serpentine”, Metabolic Engineering, 6:268-276 (2004).
    56. Berríos-Rivera, S. J., San, K.-Y., and Bennett, G. N., "The Effect of Carbon Sources and Lactate Dehydrogenase Deletion on 1,2-Propanediol Production in Escherichia coli”, Journal of Industrial Microbiology and Biotechnology, 30: 34-40 (2003).
    57. Hong, S.-B., Hughes, E.H., Shanks, J.V., San, K.-Y., and Gibson, S. I., *Role of the Non-Mevalonate Pathway in Indole Alkaloid Production by Catharanthus roseus Hairy Roots”, Biotechnology Progress, 19: 1105 – 1108 (2003).
    58. Berríos-Rivera, S. J., San, K.-Y., and Bennett, G. N., "The Effect of Carbon Sources and Lactate Dehydrogenase Deletion on 1,2-Propanediol Production in Escherichia coli”, Journal of Industrial Microbiology and Biotechnology, in press (2002).
    59. Hughes, E. H., Hong, S.-B., Shanks, J. V., San, K.-Y., Gibson, S. I., “Characterization of an Inducible Promoter System in Catharanthus roseus Hairy Roots”, Biotechnology Progress, in press (2002).
    60. San, K.-Y. , A. Saterbak, and L. V. McIntire, “A New Cellular and Molecular Engineering Curriculum at Rice University”  to be presented at the 2002 ASEE Annual Conference, Montréal, Quebec Canada, June 15-19, 2002.
    61. Berríos-Rivera, S. J., Bennett, G. N., and San, K.-Y. San, “Metabolic Engineering of Escherichia coli through Genetic Manipulation of NADH Availability”, Metabolic Engineering, 4: 217-229 (2002).
    62. Berríos-Rivera, S. J., Bennett, G. N., and San, K.-Y., “The Effect of Manipulating NADH Availability on the Redistribution of Metabolic Fluxes in Escherichia coli Chemostat Cultures”, Metabolic Engineering, 4: 230-237 (2002).
    63. Berríos-Rivera, S. J., San, K.-Y., and Bennett, G. N., “The Effect of Anprtase Overexpression on the Total Levels Of NAD, the NADH/NAD+ Ratio, and the Distribution of Metabolites in Escherichia coli”, Metabolic Engineering, 4: 238-247 (2002).
    64. San, K.-Y., Bennett, G.N., Berríos-Rivera, S.J., Vadali, R.V., Yang, Y.-T., Horton, E., Rudolph, F.B., Berna Sariyar, B., Backwood, K., "Metabolic Engineering through Cofactor Manipulation and Its Effects on Metabolic Flux Redistribution in Escherichia coli”, Metabolic Engineering, 4:182-192 (2002).
    65. Wardwell, S.A., Yang, Y.-T., Chang H.-Y., San, K.-Y., Rudolph, F.B., Bennett, G.N., “Expression of the Klebsiella pneumoniae CG21 Acetoin Reductase Gene in Clostridium acetobutylicum ATCC 824”, J Ind Microbiol Biotechnol, 27:220-7 (2001).
    66. Saterbak, A., San, K.-Y. and McIntire, L.V., “Development of a Novel Foundation Course for Biomedical Engineering Curriculum”, ASEE Annual Conference Proceedings (2001).
    67. Yang, Y.-T, Bennett, G. N., and San, K.-Y., “The Effects of Feed and Intracellular Pyruvate Levels on the Metabolic Fluxes Redistribution in Escherichia coli with Fermentative Lactate Dehydrogenase Overexpression”, Metabolic Engineering, 3:115-123 (2001).
    68. Bennett, G.N. and San, K.-Y., "Microbial Formation, Biotechnological Production and Applications of 1,2-Propanediol", App. Micro. Biotech., 55:1-9 (2001).
    69. Yang, Y.-T, Peredelchuk, M., Bennett, G. N., and San, K.-Y., “The Effect of Variation of Klebsiella pneumoniae Acetolactate Synthase Expression on Metabolic Fluxes Redistribution in Escherichia coli”, Biotechnology and Bioengineering, 69:150-159 (2000).
    70. Susana J. Berríos-Rivera, Yang, Y.-T., Bennett, G. N., San, K.-Y., “Effect of Glucose Analog Supplementation on Metabolic Flux Distribution in Anaerobic Chemostat Cultures of Escherichia coli” Metabolic Engineering, 2:149-154 (2000).
    71. Yang, Y.-T, Bennett, G. N., and San, K.-Y., “The Interactions of nuo and ack/pta Mutations on Metabolic Flux Redistribution in Escherichia coli”, Biotechnology and Bioengineering, 65:291-297 (1999).
    72. Yang, Y.-T, Bennett, G. N., and San, K.-Y., “Redistribution of Metabolic Fluxes in Escherichia coli with Fermentative Lactate Dehydrogenase Overexpression and Deletion”, Metabolic Engineering, 1:141-152 (1999).
    73. Aristidou, A.A., Bennett, G. N., and San, K.-Y., "Metabolic Flux Analysis of Escherichia coli Expressing the Bacillus subtilis Acetolactate Synthase in Batch and Continuous Cultures", Biotechnology and Bioengineering, 63:737-749 (1999).
    74. Aristidou, A.A., Bennett, G. N., and San, K.-Y., “Improvement of Biomass Yield and Recombinant Gene Expression in Escherichia coli by Using Fructose as the Primary Carbon Source”, Biotechnology Progress, 15(1)140-145 (1999).
    75. Yang, Y.-T., Bennett, G. N., and San, K.-Y., “Metabolic Flux Analysis of E. coli Deficient in the Acetate Production Pathway and Expressing the B. subtilis Acetolactate Synthase”, Metabolic Engineering, 1: 26-34 (1999).
    76. Yang, Y.-T., Bennett, G. N., and San, K.-Y., “Genetic and Metabolic Engineering”, Electronic Journal of Biotechnology, Vol 1(3) (1998).
    77. Liu, C. H., Niranjan, S. C., Clark, J. W. Jr., San, K. Y., Zwischenberger, J. B. and Bidani, A., “Airway Mechanics, Gas Exchange and Blood Flow in a Nonlinear Model of the Human Lung”, J Appl Physiol (HEG), 84 (4): 1447-69 (1998).
    78. Berríos-Rivera, S. J., Yang, Y.-T., San, K.-Y. and G. N. Bennett, “Effect of Glucose Analog Supplementation in Anaerobic Chemostat Cultures of Escherichia coli”, Proc. XVIII Interamerican Congress of Chemical Engineering, San Juan, Puerto Rico, December (1998).
    79. Chou, C,-H., Bennett, G.N. and San, K.-Y., “Genetic Manipulation of Stationary-Phase Genes to Enhance Recombinant Protein in Escherichia coli”, Biotech. Bioeng., 50:636-642 (1996).
    80. San, K.-Y. and Bennett, G.N., "Expressions Systems for DNA Processes", in the "Encyclopedia of Molecular Biology: Fundamentals and Applications", Meyers, R.A. (ed.), VCH, New York., p.271-278 (1996).
    81. Chou, C. H., Aristidou, A. A., Meng, S.Y., Bennett, G.N., and San, K.-Y., "Characterization of a pH-Inducible Promoter System for High Level Expression of Recombinant Proteins in Escherichia coli", Biotech. Bioeng., 47:186-192 (1995).
    82. Aristidou, A. A., Bennett, G.N., and San, K.-Y., "Metabolic Engineering of Escherichia coli to Enhance Recombinant Protein Production through Acetate Reduction", Biotechnology Progress, 11:475-478 (1995).
    83. San, K.-Y. and Bennett, G.N., "Expressions Systems for DNA Processes", in the "Encyclopedia of Molecular Biology and Biotechnology", Meyers, R.A. (ed.), VCH, New York, p. 306-310 (1995).
    84. Chou, C.-H., Bennett, G. N. and San, K.-Y., "Effect of Modulated Glucose Uptake on High-Level Recombinant Protein Production in a dense Escherichia coli Dense Culture", Biotechnology Progress, 10:644-647 (1994).
    85. Niranjan, S.C., Clark, J.W., San, K.-Y., Zwischenberger, J.B., and Bidani, A., "Mathematical Analysis of Gas Exchange in an Intravascular Blood Gas Exchanger (IVOX)", J. Applied Physiology, 77(4):1716-1730 (1994).
    86. Niranjan, S.C., Clark, J.W. , San, K.-Y., Zwischenberger, J.B., and Bidani, A., "Simulation of Gas Transport in an Intravenacaval Blood-Gas Exchanger Device (IVOX)", Proc. International Federation of Automatic Control Symposium on Modeling and Control in Biomedical Systems, Galveston, Tx., pp.198-201 (1994).
    87. Liu, C.H., Niranjan, S. C., Clark, J.W., San, K.-Y. San, and Bidani, A., "Analysis of Airway Mechanisms in a Ventilated Lumped Alveolar Model Coupled with Pulmonary Gas Exchange", Proc. International Federation of Automatic Control Symposium on Modeling and Control in Biomedical Systems, Galveston, TX., pp527-530 (1994).
    88. Chou, C.-H., Bennett, G. N. and San, K.-Y., "Effect of Modified Glucose Uptake using Genetic Engineering Techniques on High-Level Recombinant Protein Production in Escherichia coli Dense Cultures", Biotech. Bioeng., 44:952-960 (1994).
    89. Aristidou, A. A., San, K.-Y., and Bennett, G.N., "Modification of Central Metabolic Pathway in Escherichia coli to Reduce Acetate Accumulation by Heterologous Expression of the Bacillus subtilis Acetolactate Synthase Gene", Biotech. Bioeng., 44:944-951 (1994).
    90. San, K.-Y., G. N. Bennett, Aristidou, A.A., C-H Chou, A.A., "Strategies in High Level Expression of Recombinant Protein in Escherichia coli", Annals of the New York Academy of Sciences, Vol 721, 257-267 (1994).
    91. San, K.-Y., G. N. Bennett, C-H Chou, and Aristidou, A.A., "An Optimization Study of a pH-Inducible Promoter System for High Level Recombinant Protein Production in Escherichia coli", Annals of the New York Academy of Sciences, Vol 721, 268-277 (1994).
    92. Yu, P., and San, K.-Y., "Continuous Production of Cell-Free Recombinant Proteins Using Escherichia coli", Biotechnology Progress, 9:587-593 (1993).
    93. Aristidou, A. A., Yu, P., and San, K. -Y., "Effects of Glycine Supplement on Enzyme Production and Release in Recombinant Escherichia coli", Biotechnology Letters, 15, 331-336 (1993).
    94. Pollard, J.F., Broussard, M.R., Garrison, D.B., and San, K.-Y., "Process Identification using Neural Networks", Computers in Chemical Engineering, 16:253-270 (1992).
    95. Tolentino, G.J., Meng, S.Y., Bennett, G.N., and San, K.-Y., "A pH-Regulated Promoter for the Expression of Recombinant Proteins in Escherichia coli", Biotechnol. Lett. 14:157-162 (1992).
    96. Yu, P., and San, K. -Y., “Protein Release in Recombinant Escherichia coli Using Bacteriocin Release Protein", Biotechnology Progress, 8, 25-29 (1991).
    97. Yu, P., Aristidou, A. A., and San, K.-Y., "Synergistic Effect of Glycine and Bacteriocin Release Protein in the Release of Periplasmic Protein in Recombinant E. coli", Biotechnology Letters, 13 (5), 311-316 (1991).
    98. Weber, A.E., Yu, E., and San, K.-Y., "The Effect of the Partition Locus on Plasmid Stability and Expression of a Prolonged Chemostat Culture", J. of Biotechnology, 18, 141-152 (1991).
    99. Weber, A.E. and San, K.-Y., "Population Dynamics of a Recombinant Culture in a Chemostat under Prolonged Cultivation", Biotech. Bioeng., 36, 727-736 (1990).
    100. Cardello, R.J. and K.-Y. San, "Process Analysis and Identification with a Real Time Intelligent Bioreactor Supervisory Controller", Automatic Control Conference, pp. 2167-2172, San Diego, Ca, (1990).
    101. San, K.-Y., and McIntire, L.V., "A Program on Biochemical and Biomedical Engineering", Chemical Engineering Education, 23, 200-203 (1989).
    102. Cardello, R.J. and San K.-Y., "Design and Real-Time Implementation of an Intelligent Bioreactor Control System", Proc. 1989 Automatic Control Conference, Pittsburgh, PA, 2411-2417 (1989).
    103. Weber, A.E. and San, K.-Y., "A Comparison of Two Plating Techniques to Estimate Plasmid Stability of a Prolonged Chemostat Culture", Biotechnol. Techniques, 3, 397-400 (1989).
    104. Weber, A.E. and San, K.-Y., "Dynamics of Plasmid Maintenance in a CSTR upon Square-Wave Perturbations in the Dilution Rate", Biotech. Bioeng., 34, 1104-1113 (1989).
    105. Niranjan, S.C. and K.-Y. San, "Analysis of a Framework Using Material Balances in Metabolic Pathways to Elucidate Cellular Metabolism", Biotech. Bioeng., 34, 496-501 (1989).
    106. San, K.-Y. and Stephanopoulos, G., "Optimization of Fed-batch Penicillin Fermentation. A Case of Optimal Control of Singular Sys-tems with State Constraints", Biotech. Bioeng., 34, 72-78 (1989).
    107. San, K.-Y. and Weber, A.E., "Data Analysis of Plasmid Maintenance in a CSTR", Biotech. Bioeng., 33, 451-459 (1989).
    108. Weber, A.E. and San, K.-Y., "Enhanced Plasmid Maintenance in a CSTR upon Square-Wave Perturbations in the Dilution Rate", Biotechnol. Lett., 10, 531-536 (1988).
    109. Niranjan, S.C. and K.-Y. San, "Optimal Feedback Control of a Bioreactor with a Remote Sensor", Proc. 1988 Automatic Control Con-ference, Atlanta, Georgia, 1106-1111 (1988).
    110. San, K.-Y., Papoutsakis, E.T., and Stephanopoulos, G.N., "Measurements, Data Analysis and Control", In Handbook on Anaerobic Fermenta-tions, Erickson, L.E. and Fung D. (Eds.). Chapter 14, p. 441-462, Marcel Dekker Inc., New York (1988).
    111. Cardello R.J. and San, K.-Y., "The Design of Controllers for Batch Bioreactors", Biotech. Bioeng., 32, 519-526 (1988).
    112. Tolentino G.J. and San, K.-Y., "Plasmid Maintenance and Gene Ex-pression under Aerobic and Anaerobic Conditions" Biotechnol. Lett., 10, 373-376 (1988).
    113. Niranjan, S.C. and K.-Y. San, "Optimal Feedback Control of a Bioreactor with a Remote Sensor", Proc. 1988 Automatic Control Con-ference, Atlanta, Georgia, 1106-1111 (1988).
    114. Weber, A.E. and San, K.-Y., "Persistence and Expression of the Plasmid pBR322 in Escherichia coli K12 Cultured in a Complex Medium", Biotechnol. Lett., 9, 757-760 (1987).
    115. Cardello R.J. and San, K.-Y., "Application of Gain Scheduling to the Control of Batch Bioreactors", Proc. 1987 Automatic Control Conference, Minneapolis, Minnesota, 682-686 (1987).
    116. Weber A.E. and San, K.-Y., "Effects of Square-Wave Perturbations in Dilution Rate on Plasmid Maintenance and Gene Expression", Bioprocess Engineering Colloquium, ASME Winter Annual Meeting, Boston, Massachusetts, p. 75-78, Dean, R.C., Jr. and Nerem, R.M. (Eds) (1987).
    117. Cardello R.J., Broussard M.R. and San, K.-Y., "Development of an Expert System Based Bioreactor Control Scheme", Bioprocess Engineering Colloquium, ASME Winter Annual Meeting, Boston, Massachusetts, p. 21-24, Dean, R.C., Jr. and Nerem, R.M. (Eds) (1987).
    118. San, K.-Y. and Stephanopoulos, G.N., "The Effect of Growth Rate De-lays on the Optimal Profile of Fed-batch Reactors", Biotech. Bio-eng., 28, 356-361 (1986).
    119. Davison, B.H., San, K.-Y. and Stephanopoulos, G.N., "Stable Compe-tition Coexistence in a Continuous Fermentor with Size-selective Proper-ties", Biotechnol. Progress, 1, 260-269 (1985).
    120. Stephanopoulos, G.N., San, K.-Y. and Davison, B.H., "A Novel Bioreactor-cell Precipitator Combination for High-cell Density, High Flow Continuous Fermentations", Biotechnol. Progress, 1, 250-259 (1985).
    121. San, K.-Y. and Stephanopoulos, G.N., "A Note on the Optimality Cri-teria for Maximum Biomass Production in a Fed-Batch Reactor", Biotech. Bioeng., 26, 1261-1264 (1984).
    122. San, K.-Y. and Stephanopoulos, G.N., "Studies on On-line Bioreactor Identification, Part IV - Utilization of pH Measurements for Product Estimation", Biotech. Bioeng., 26, 1209-1218 (1984).
    123. Grosz, R., Stephanopoulos, G.N. and San, K.-Y., "Studies on On-line Bioreactor Identification, Part III - Sensitivity Problems with Res-piration Quotient and Heat Evolution Measurements", Biotech. Bioeng., 26, 1198-1208 (1984).
    124. San, K.-Y. and Stephanopoulos, G.N., "Studies on On-line Bioreactor Identification, Part II - Numerical and Experimental Results", Biotech. Bioeng., 26, 1189-1197 (1984).
    125. Stephanopoulos, G.N. and San, K.-Y., "Studies on On-line Bioreactor Identification, Part I - Theory", Biotech. Bioeng., 26, 1176-1188 (1984).
    126. Stephanopoulos, G.N. and San, K.-Y., "On the Continuous Monitoring of Time Varying Parameters", Proc. 1st IFAC Symp. on Biotechnical Processes, 195-199 (1983).
    127. San, K.-Y. and Stephanopoulos, G.N., "Optimal Control Policy for Substrate Inhibited Kinetics with Enzyme Deactivation in an Isothermal CSTR", AIChE. J., 29, 417-424 (1983).
    128. Stephanopoulos, G.N. and San K.-Y., "On-Line Estimation of the State of Biochemical Reactors", Proc. of ISCRE-7, ACS Symposium Series 196, J. Wei and C. Georgakis (eds.), 155-164 (1982).
    129. Stephanopoulos, G.N. and San K.-Y., "State Estimation for Computer Control of Biochemical Reactors", Proc. 6th Fermentation Symposium, July 15-20, 1981, London, Canada, vol. 1, 399-407, M. Moo-Young, C.W. Robinson, C. Vezino (eds.)(1981).

 

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