Peer reviewed original research papers grouped by topic.
For a complete list of publications please see


Multi-Domain Peptide (MDP) Nanofibers

  • 13. N. C. Wickremasinghe, V. A. Kumar, J. D. Hartgerink "Two Step Self-assembly of Liposome-Multidomain Peptide Nanofiber Hydrogel for Time-Controlled Release" Biomacromolecules, in press.

  • 12. M. K. Kang, J. Colombo, R.N. D'Souza, J. D. Hartgerink "Sequence effects of self-assembling MultiDomain Peptide Hydrogels on encapsulated SHED cells" Biomacromolecules, 15, 2004-2011 (2014).

  • 11. E. L. Bakota, O. Sensoy, B. Ozgur, M. Sayar, and J. D. Hartgerink "Self-Assembling Multidomain Peptide Fibers with Aromatic Cores" Biomacromolecules 14, 1370-1378 (2013).

  • 10. K. M. Galler, J. D. Hartgerink, A. C. Cavender, G. Schmalz and R. N. D'Souza "A Customized Self-Assembling Peptide Hydrogel for Dental Pulp Tissue Engineering" Tissue Eng. A13, 176-184 (2012).

  • 9. K. M. Galler, R. N. D'Souza, M. Federlin, A. C. Cavender, J. D. Hartgerink, S. Hecker, G. Schmalz "Dentin Conditioning Codetermines Cell Fate in Regenerative Endodontics" J. Endo. 37, 11, 1536-1541 (2011).

  • 8. E. L. Bakota, Y. Wang, F. Danesh, and J. D. Hartgerink "Injectable Peptide Nanofiber Hydrogel as Delivery Agent for Stem Cell Secretome"
    Biomacromolecules, 12, 1651-1657 (2011).

  • 7. Y. Wang, E. Bakota, B. H. J. Chang, M. Entman, J. D. Hartgerink, and F. R. Danesh "Peptide Nanofibers Preconditioned with Stem Cell Secretome Are Renoprotective"
    J. Am. Soc. Nephrology, 22, 704-711 (2011).

  • 6. E. L. Bakota, L. Aulisa, K. M. Galler, and J. D. Hartgerink "Enzymatic Cross-Linking of a Nanofibrous Peptide Hydrogel"
    Biomacromolecules, 12 82-87 (2011).

  • 5. K. M. Galler, L. Aulisa, K. R. Regan, R. N. D'Souza and J. D. Hartgerink "Self-assembling Multidomain Peptide Hydrogels: Designed Susceptibility to Enzymatic Cleavage Allows Enhanced Cell Migration and Spreading"
    J. Am. Chem. Soc., 132, 3217-3223 (2010).

  • 4. L. Aulisa, H. Dong and J. D. Hartgerink "Self-Assembly of Multidomain Peptides: Sequence Variation Allows Control over Cross-Linking and Viscoelasticity"
    Biomacromolecules, 10, 2694-2698 (2009).

  • 3. E. L. Bakota, L. Aulisa, D. A. Tsyboulski, R. B. Weisman and J. D. Hartgerink " Multidomain Peptides as Single-Walled Carbon Nanotube Surfactants in Cell Culture"
    Biomacromolecules, 8 2201-2206 (2009).

  • 2. D. Tsyboulski, E. Bakota, L. Witus, J-D. Rocha, J. D. Hartgerink, B. R. Weisman "Self-Assembling Peptide Coatings Designed for Highly Luminescent Suspensions of Single-Walled Carbon Nanotubes"
    J. Am. Chem. Soc. 130, 17134-17140 (2008).

  • 1. H. Dong, S. E. Paramonov, L. Aulisa, E. L. Bakota, and J. D. Hartgerink "Self-Assembly of Multi-Domain Peptides: Balancing Molecular Frustration Controls Conformation and Nanostructure"
    J. Am. Chem. Soc. 129, 12468-12472 (2007).

Collagen-like Peptides (CLPs)

Alpha-Helical Peptides


  • 8. D. Zhang, O. Neumann, H. Wang, V. M. Yuwono, A. Barhoumi, M. Perham, J. D. Hartgerink, P. Wittung-Stafshede and N. J. Halas "Gold Nanoparticles Can Induce the Formation of Protein-based Aggregates at Physiological pH"
    Nano Lett. 9, 666-671 (2009).

  • 7. C. L. Pizzey, W. C. Pomerantz, B.-J. Sung, V. M. Yuwono, S. H. Gellman, J. D. Hartgerink, A. Yethiraj, and N. L. Abbott "Characterization of nanofibers formed by self-assembly of beta-peptide oligomers using small angle x-ray scattering"
    J. Chem. Phys. 129, 095103 (2008).

  • 6. F. Wei, D. Zhang, N. J. Halas and J. D. Hartgerink "Aromatic amino acids provide characteristic motifs in the Raman and SERS spectroscopy of Peptides"
    J. Phys. Chem. 113, 9158-9164 (2008).

  • 5. W. C. Pomerantz, V. M. Yuwono, C. L. Pizzey, J. D. Hartgerink, N. L. Abbott, S. H. Gellman, "Nanofibers and Lyotropic Liquid Crystals from a Class of Self-Assembling Beta-Peptides"
    Angew. Chem. Int. Ed. 47, 1241-1244 (2008).

  • 4. M. B. Murphy, J. D. Hartgerink, A. Goepferich, and A. G. Mikos, "Synthesis and In Vitro Hydroxyapatite Binding of Peptides Conjugated to Calcium-Binding Moieties"
    Biomacromol., 8, 2237-2243 (2007).

  • 3. J. Yang, L. B. Alemany, J. Driver, J. D. Hartgerink, A. R. Barron "Fullerene-derivatized amino acids: Synthesis, characterization, antioxidant properties, and solid-phase peptide synthesis"
    Chem. Eur. J., 13, 2530-2545 (2007).

  • 2. C. S. Levin, B. G. Janesko, R. Bardhan, G. E. Scuseria, J. D. Hartgerink, N. J. Halas "Chain-Length-Dependent Vibrational Resonances in Alkanethiol Self-Assembled Monolayers Observed on Plasmonic Nanoparticle Substrates"
    Nanoletters 6, 2617-2621 (2006).

  • 1. M. J. Pender, L. A. Sowards, J. D. Hartgerink, M. O. Stone, R. R. Naik "Peptide-Mediated Formation of Single-Wall Carbon Nanotube Composites"
    Nanoletters 6, 40-44 (2006).

Peptide-Amphiphiles (PAs)

  • 8. L. Aulisa, N. Forraz, C. McGuckin, J. D. Hartgerink "Inhibition of Cancer Cell Proliferation by Designed Peptide-Amphiphiles"
    Acta Biomaterialia 5, 842-853 (2009).

  • 7. K. M. Galler, A. Cavender, V. Yuwono, H. Dong, S. Shi, G. Schmalz, J. D. Hartgerink and R. N. D'Souza "Self-Assembling Peptide Amphiphile Nanofibers as a Scaffold for Dental Stem Cells"
    Tissue Eng. 14, 2051-2058 (2008).

  • 6. H-W. Jun, S. E. Paramonov, H. Dong, N. Forraz, C. McGuckin, and J. D. Hartgerink "Tuning the mechanical and bioresponsive properties of peptide-amphiphile nanofiber networks"
    J. Biomater. Sci. Polymer Edn. 19, 665-676 (2008).

  • 5. Virany M. Yuwono and Jeffrey D. Hartgerink "Peptide Amphiphile Nanofibers Template and Catalyze Silica Nanotube Formation"
    Langmuir 23, 5033-5038 (2007).

  • 4. L. S. Witus, J.-D. R. Rocha, V. M. Yuwono, S. E. Paramonov, R. B. Weisman and J. D. Hartgerink "Peptides that non-covalently functionalize single-walled carbon nanotubes to give controlled solubility characteristics"
    J. Mater. Chem. 17, 1909-1915 (2007).

  • 3. S. E. Paramonov, H-W. Jun "Self-assembly of peptide-amphiphile nanofibers: the roles of hydrogen bonding and amphiphilic packing"
    J. Am. Chem. Soc. 128, 7291-7298 (2006).

  • 2. S. E. Paramonov, H-W. Jun, J. D. Hartgerink "Modulation of Peptide-Amphiphile Nanofibers via Phospholipid Incusions"
    Biomacromol. 7, 24-26 (2006).

  • 1. H-W Jun, V. Yuwono, S. E. Paramonov, J. D. Hartgerink "Enzyme Mediated Degradation of Peptide-Amphiphile Nanofiber Networks"
    Adv. Mater. 17, 2612-2617 (2005).