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Biosystems
Biosystems engineering focuses on the integration of molecular biology,
protein engineering and high throughput technologies with systems modeling
methodological approaches. It aims at: a) first obtaining a complete (vs by
parts) understanding of the biological system, from the molecular up to the
cell population level and b) developing and applying strategies to engineer
(design, optimize and control) its performance in general.
Recent advances in information biology and techniques to monitor and modify
systems at the molecular scale provide unprecedented opportunities to model
and then tailor biochemical systems for medical and industrial applications.
Previous research in the biosciences area has focused on understanding the
relationship between inputs and outputs in biological systems without detailed
knowledge of the internal workings of the biological system. However, newly
developed experimental tools provide unique opportunities for probing the
details of complex biological systems. The goal now is not just to understand
the functions
of individual genes, proteins and smaller molecules like hormones, but to
learn how all of these molecules interact within the cell, as well as how
cells function
as components of cell populations and tissues.
Motivated by these challenges and opportunities, Professors Mantzaris and
Zygourakis are
collaborating with a group of faculty from Biochemistry and Cell Biology,
Bioengineering, Computational and Applied Mathematics, Statistics and Chemistry
to develop novel frameworks that combine experimental, theoretical and
computational tools to study heterogeneous cell populations as complex,
and highly interconnected
systems with interacting components. This novel systems-based approach
will change the design principles used to develop effective drugs, tissues
with
desirable structure, materials with novel properties, and other bio-based,
environmentally friendly, and sustainable technologies.
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