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Deepak Nagrath
- Cellular Systems Engineering Laboratory
Positions Available
- Positions available for students and a postdoc. Please contact Prof. Nagrath for more information.
Department of Chemical and Biomolecular Engineering
MS-362
P.O. Box 1892
Rice University
Houston, TX 77251-1892
E-mail:
deepak.nagrath@rice.edu
(713) 348-6408
(713) 348-5478
Abercrombie Lab, B233
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 Deepak Nagrath
Assistant Professor in Chemical and Biomolecular Engineering
Research Interests:
- Network Systems Biology
- Nutritional Systems Biology
- Cellular Reprogramming into Embryonic Stem Cells
- Disease Systems Biology
- Cancer Metabolism
- Cellular and Metabolic Tissue Engineering
Education:
- B.Tech. (1992) Indian Institute of Technology, Roorkee
- M.S. (2000) Rensselaer Polytechnic Institute
- Ph.D. (2003) Rensselaer Polytechnic Institute
- Postdoctoral Research Fellow (2003-2006) Harvard Medical School/Massachusetts General Hospital/Shriners Burn Hospital
- Research Associate (2007-2009) Harvard Medical School/Massachusetts General Hospital/Shriners Burn Hospital
Dr. Nagrath's research interests lie in the application of nutritional
systems-biology approaches in highly challenging, cutting edge problems in
clinical disciplines such as metabolic syndrome, liver fibrosis, and
regenerative medicine. Nutritional systems biology (NSB) is defined as
the approach to understand the key processes that regulate metabolism at all
levels of complexity and to predict the outcome of any alteration of the
system by utilizing metabolic tools. He uses transcriptional and metabolic
design principles to analyze healthy and diseased biological states. His
research focuses on various diseases such as metabolic syndrome, cancer,
and diabetes, and potential treatments using metabolic supplementation and
embryonic stem cells. Dr. Nagrath makes a concerted effort to use engineering
principles, such as multiobjective optimality and nonequilibrium
thermodynamics, for analyzing complex disease states. His research
integrates both experimental and theoretical tools to develop a recipe for
maintaining normal function of various organs.
The goal of his work is to offer an important window to understand the
role of environmental stress/factors interactions with the cellular components,
and in modulating those interactions optimally to improve human health. In
an effort towards understanding the energetic basis of embryonic stem
cells (ESC) transcriptional network, Professor Nagrath is focusing on developing
framework that can predict the abundance of topological motifs in the
transcriptional regulatory network using combined thermodynamics and
Pareto optimality analysis.
Modified 09/16/09
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