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Seminars
Materials
for Spatially and Temporally-Controlled Gene Delivery
Professor Suzie Pun
Department of Bioengineering
University of Washington
When: Thursday, November 30, 2006
Time: 2:30 PM to 3:30 PM
Where: 1070 Duncan Hall
Abstract:
Localized gene delivery has important applications such as tissue engineering,
drug delivery and functional genomics. For example, gene delivery vehicles
can be integrated with implanted biomedical devices to improve integration
with host tissue or incorporated in tissue engineering scaffolds to promote
functional tissue growth. Several design considerations exist for optimal
application of this technology. The delivery vehicles should be combined
with the delivery substrate without compromising delivery efficiency. In
addition, the ability to spatially and temporally control transgene expression
is desirable.
In this presentation, two specific systems for localized gene
delivery will be discussed. In the first system, non-viral gene
delivery vehicles are specifically immobilized on solid surfaces by a self-assembly
process driven by inclusion complex formation. These materials
can be combined
with soft lithography techniques to spatially control gene delivery
to specific subsets of cells. In the second system non-viral gene delivery
vehicles
are incorporated into the surface and bulk material of fibrin-based
scaffolds. These materials mediate two-stage gene delivery and are being
investigated
for tissue engineering applications. .
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