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Seminars
Nanoparticle Based Drug and Contrast Agent Delivery Systems
Ananth Annapragada
Department of Chemical Enginering
University of Houston
When: Thursday, September 8, 2005
Time: 2:30 PM to 3:30 PM
Where: 1064 Duncan Hall
Abstract:
Nanoparticle manipulations provide the ability to control functionality at the level of a few molecules, thus enabling highly precise control over the behavior of delivery systems. As examples of this approach, two specific technologies developed in my laboratories will be discussed:
- A Stealth liposomal contrast-agent delivery system for both CT and MR contrast provides control over the clearance kinetics of the agent, and enables new imaging protocols for cardiovascular imaging. In CT, this enables ultra high resolution images not achievable hitherto, as well as far improved methods for heart and lung imaging, relevant to a clinical Acute Chest Pain scenario. Preclinical data on these advances will be presented.
- A new class of nanoengineered agglomerates for pulmonary drug delivery. These agglomerates permit post-inhalation modulation of the drug release rate, while also extending lung residence time. This technology has been extended to produce “smart” particles, that sense physiological conditions and accordingly release their payload. The culmination of this technology is a glucose-sensing insulin-delivery system, an in vivo demonstration of which will be presented.
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