Dr. Rebecca Richards-Kortum
in vivo Imaging of HPV Induced Cervical Carcinogenesis
We develop novel cell and molecular imaging modalities
to improve the early detection and treatment of cancer.
We focus on cancers of the oral cavity, the lung and the
cervix which represent more than 20% of both tumor incidence
and mortality worldwide. The goal of this project is to
develop and test contrast agents to label cervical epithelial
cells expressing high levels of proteins associated with
high-risk HPV infection. The contrast agents will be based
on gold nanoparticles attached to monoclonal antibodies
specific for proteins associated with HPV induced cervical
carcinogenesis. We will test these contrast agents in a
chronic estrogen induced cervical cancer model in HPV 16
transgenic mice.
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