Matthew Wettergreen, Ph.D. Candidate

Interests:

Matthew Wettergreen is a Ph.D. Candidate in the Department of Bioengineering at Rice University, Houston, TX. He received his B.S. degree in Bioengineering from the University of Illinois at Chicago, Chicago, IL. His current research interests are in the characterization and determination of relationships with govern the effect of material arrangement on structural properties of three-dimensional porous objects. His thesis title is:

"Investigation of Surface Mechanical Environment as an Optimization Criterion for Improved Tissue Engineering Scaffolds",

Publications:

Book Chapters

1.     Bucklen B., Wettergreen M., Liebschner M.: "Mechanical Aspects of Tissue Engineering". In Seminars in Plastic Surgery/Publisher Thieme on the topic of "Tissue Repair, Regeneration and Engineering in Plastic Surgery". Editors: Dr. C. Randall Harrell/Dr. Saleh M. Shenaq/Dr. Eser Yuksel. Volume 19, Number 3, 261-270,2005.

2.     Yuksel E., Choo J., Wettergreen M., Liebschner M.: "Challenges in Tissue Engineering". In Seminars in Plastic Surgery/Publisher Thieme on the topic of "Tissue Repair, Regeneration and Engineering in Plastic Surgery". Editors: Dr. C. Randall Harrell/Dr. Saleh M. Shenaq/Dr. Eser Yuksel. Volume 19, Number 3, 217-228, 2005.

3.     Wettergreen M., Bucklen B., Liebschner M.: "CAD assembly process for bone replacement scaffold in Computer-Aided Tissue Engineering". In Virtual & Rapid Prototyping in Medicine, Part II - Bio-Manufacturing. Editors: Bidanda B. and Bˆ°rtolo P. Springer. In Press.

Peer Reviewed Publications

1.     Bucklen B., Wettergreen M., Heinkenschloss M., Liebschner M.: "Surface-Based Scaffold Design: A Mechanobiological Approach." IMECE 2005, Advances in Bio-Manufacturing. IMECE2005-81985.

2.     Wettergreen M., Bucklen  G., Sun W., Liebschner M.: "Computer-Aided Tissue Engineering in Whole Bone Replacement Treatment". IMECE 2005, Advances in Bio-Manufacturing. IMECE2005-82000.

3.     Wettergreen M., Bucklen B., Starly B., Yuksel E., Sun W., Liebschner M.: "Unit Block Library of Basic Architectures for use in Computer-aided Tissue Engineering of Bone Replacement Scaffolds". IMECE 2005, Advances in Bio-Manufacturing. IMECE2005-81984.

4.     Wettergreen M., Scheffe J., Mikos A., Liebschner M.: "Microparticle Fabrication for Tissue Engineering Applications using Rapid Prototyping and Soft Lithography Principles". IMECE 2005, Advances in Bio-Manufacturing. IMECE2005-81990.

5.     Wettergreen M., Bucklen B., Templeton A. Sun W., Liebschner M.: "Computer Aided Tissue Engineering of Human Vertebral Body." Annals of Biomedical Engineering, 33(10): 1333-1343, 2005.

6.     Wettergreen M., Bucklen B., Starly B., Yuksel E., Sun W., Liebschner M.: "Creation of a Unit Block Library of Architectures for Use in Assembled Scaffold Engineering." Computer-Aided Design, Special Issue: Bio-CAD, 37(11): 1141-49, 2005.

Submitted and in Preparation

7.  Bucklen B., Wettergreen M., Yuksel E., Liebschner M.: "Bone derived CAD library for the assembly of scaffolds in Computer-Aided Tissue Engineering." Acta Biomaterialia, Submitted.

8.  Lemoine J., Wettergreen M., Liebschner M.: "Calibration of Micro-Computed Tomography Scans for Measurement of Bone Mineral Density." Medical Engineering & Physics. Submitted.

9.  Bucklen B., Wettergreen M., Liebschner M.: " What is the Driving Force Behind Mechanical Adaptation of Trabecular Bone? : A Parametric Finite Element Study." Bone, Submitted.

10.  Wettergreen M., Abbe R., Sun K., Hess K., Rhines L., Liebschner M.: "Modulation of Drug Release Kinetics of Doxorubicin from Composite Poly(Methyl Methacrylate) Bone Cements." Biomaterials, Submitted.

11.  Wettergreen M., Bucklen B., Mikos A., Liebschner M.: ’ÄúStructural Properties of Regular Architectures, Part 1: Geometric Characterization and Finite Element Structural Comparison of Platonic and Archimedian Solids’Äù. In Preparation.

12.  Wettergreen M, Lemoine J, Mikos A, Liebschner M.: "Rapid Prototyping Process for the Fabrication of Porogens". Rapid Prototyping Journal. In Preparation.

13.  Wettergreen M, Scheffe J, Mikos A, Liebschner M.: "Microparticle Fabrication for Tissue Engineering Applications using Rapid Prototyping and Soft Lithography Principles". Rapid Prototyping Journal. In Preparation.

14.  Wettergreen M., Timmer M., Horch A., Mikos A., Liebschner M.: "Critical Evaluation of a Fused Deposition Modeling Process for the Creation of Inter-Connected Scaffolds Using a Negative Molding Process." Rapid Prototyping. In Preparation.

15.  Wettergreen M., Sun K., Liebschner M.: "Finite Element Analysis of a Novel Bone Anchor Concept." Journal of Biomechanics. In Preparation.

Conference Presentations:

1.         Bucklen B., Wettergreen M., Liebschner M.: "Driving Force Behind Mechanical Adaptation of Trabecular Bone Tissue: A Parametric FEA Study". 2006 Annual Fall Meeting Biomedical Engineering Society, October 11-14, Chicago, IL, 2006.

2.         Wettergreen M., Abbe R., Sun K., Hess K.,  Rhines L., Liebschner M.: "Injectable Bi-Phasic Bone Cement for the Therapeutic Release of Chemotherapeutic Agents". 2006 Annual Fall Meeting Biomedical Engineering Society, October 11-14, Chicago, IL, 2006.

3.         Wettergreen M., Bucklen B., Liebschner M.: " Assembly of Trabecular Bone Derived Scaffold Micro-Architectural for Patient Specific Applications". 2006 Annual Fall Meeting Biomedical Engineering Society, October 11-14, Chicago, IL, 2006.

4.         Wettergreen M., Bucklen B., Liebschner M., Wei S.: "Design and Characterization of Cellular Solids from Modeling through Solid Freeform Fabrication". 17^th Solid Freeform Fabrication Symposium, Austin, Texas, 14-16 August, 2006.

5.         Wettergreen M., Sun W., Abbe R., Rhines L., Liebschner M.: "Controlled Drug Release from Composite Orthopaedic Bone Cement." Transcript, Orthopaedic Research Society (ORS), Chicago, IL, March 19 - 22, 2006.

6.         Bucklen B., Wettergreen M., Heinkenschloss M., Liebschner M.: "Surface-Based Scaffold Design: A Mechanobiological Approach."  Advances in Bio-Manufacturing, ASME  IMECE 2005, Orlando, FL, November 5-11, 2005.

7.         Wettergreen M., Bucklen B., Sun W., Liebschner M.: "Computer-Aided Tissue Engineering in Whole Bone Replacement Treatment." Advances in Bio-Manufacturing, ASME  IMECE 2005, Orlando, FL, November 5-11, 2005.

8.         Wettergreen M., Scheffe J., Mikos A., Liebschner M.: "Microparticle Fabrication for Tissue Engineering Applications using Rapid Prototyping and Soft Lithography Principles." Advances in Bio-Manufacturing, ASME  IMECE 2005, Orlando, FL, November 5-11, 2005.

9.         Wettergreen M., Bucklen B., Starly B., Yuksel E., Sun W., Liebschner M.: "Unit Block Library of Basic Architectures for Use in Computer-Aided Tissue Engineering of Bone Replacement Scaffolds." Advances in Bio-Manufacturing, ASME  IMECE 2005, Orlando, FL, November 5-11, 2005.

10.         Tawackoli W., Lemoine J., Wettergreen M., Rajapakse C., Gunaratne G., Spanos P., Liebschner M.: "Vibrational Analysis of Normal and Osteopenic Trabecular Bone Using Rapid Prototyped Duplicates." Joint Meeting: International Society of Biomechanics and American Society of Biomechanics, Cleveland, Ohio, July 31 - August 5, 2005.

11.         Wettergreen M., Sun W., Mikos A., Liebschner M.: "Geometric Characterization of Scaffold Building Blocks for Tissue Engineering." Transcript, Orthopaedic Research Society (ORS), February 20 - 23, 2005, Washington, D.C.

12.         Wettergreen M., Bucklen B., Mikos A.G., Liebschner M.: "Tailoring the Mechanical Environment of Scaffolds with Computer Aided Design and Rapid Prototyping." 2004 Annual Fall Meeting Biomedical Engineering Society, October 13-16, Philadelphia, PA, 2004.

13.         Yuksel E., Bienstock A., Wettergreen M., Liebschner M., Shenaq S.:" Ear reconstruction in Microtia and Traumatic Defects: A Novel Prefabricated Flap Design". Plastic Surgery 2004, October 9-13, Philadelphia, PA, 2004.

14.         Wettergreen M., Pan J., Lemoine J., Mikos A.G., Liebschner M.: "Modification of Apparent Scaffold Properties Through Porogen Surface to Volume Ratio Manipulation." Transcript, Orthopaedic Research Society (ORS), San Francisco, March 7 - 10, 2004.

15.         Wettergreen M., Liebschner M.: "Permeability Prediction of Tissue Engineering Scaffolds Using Mathematical Models." 6th International Bone Fluid Flow workshop, September 30 - October 1, 2004, in Seattle, WA.

16.         Wettergreen M., Lemoine J., Liebschner M., Yuksel E.: "Optimization of Scaffold Regeneration Process Using Negative Templates Created Using Computer Aided Tissue Engineering." 49^th Annual Meeting of the Plastic Surgery Research Council, June 9-12, Ann Arbor, Michigan, 2004.

17.         Wettergreen M., Yuksel E., Liebschner M.: "Optimization of Scaffold Permeability for the Intended Increase of Tissue Vascularization in Prefabricated Implants for Tissue Engineering." 49^th Annual Meeting of the Plastic Surgery Research Council, June 9-12, Ann Arbor, Michigan, 2004.

18.         Wettergreen M., Bucklen B., Mikos A., Liebschner M.: " Scaffold Design Using Model-Based Mechanotransduction Principles." 2003 Annual Fall Meeting Biomedical Engineering Society, October 1-4, Nashville, TN, 2003.

19.         Wettergreen M., Timmer M., Mikos A., Liebschner M.: " Modification of porogen surface to volume ratio can be used to optimize the permeability of scaffolds used in tissue engineering ". Fifth International Bone Fluids Workshop, September 17-18, Cleveland, Ohio, 2003.

20.         Liebschner M., Wettergreen M., Sun K.: ’ÄúNovel internal fixation device for use in osteoporotic bone.’Äù 20st Annual Houston Conference on Biomedical Engineering Research, HSEMB 2003, April 3-4, Houston, TX, 2003.

21.         Wettergreen M., Bucklen B., Mikos A., Liebschner M.: ’ÄúScaffold Optization for Load-Bearing Applications in Orthopaedics.’Äù 20st Annual Houston Conference on Biomedical Engineering Research, HSEMB 2003, April 3-4, Houston, TX, 2003.

22.         Wettergreen M., Mikos A., Liebschner M.: ’ÄúTissue Engineered Composite Bone Cement for Reinforcing Osteoporotic Bone.’Äù 20st Annual Houston Conference on Biomedical Engineering Research, HSEMB 2003, April 3-4, Houston, TX, 2003.

23.         Wettergreen M., Mikos A., Liebschner M.: "Design of a Three-Dimensional Composite Scaffold with Varied Engineered Micro-Architecture." 13th Interdisciplinary Research Conference on Biomaterials GRIBOI 2003, Baltimore, MD, March 14th-15th, 2003.

24.         Wettergreen M., Mikos A., Liebschner M.: "Evaluation of an Injectable Composite Bone Cement with Engineered Micro-Architecture." 13th Interdisciplinary Research Conference on Biomaterials GRIBOI 2003, Baltimore, MD, March 14th-15th, 2003.

25.         Liebschner M., Wettergreen M.: ’ÄúScaffold Optimization for Load Bearing Applications.’Äù Twenty First Southern Biomedical Engineering Conference, Washington, DC, September 28-29, 2002.