BIOE 425/625� Pharmaceutical engineering
Spring 2004
Homework 6
Due� April ?
1.� (50 pts) Write a homework or case study problem based on the drug you have chosen for your research paper.� This problem could be on pharmacokinetics, membrane transport, drug delivery, or formulation design.� Grading will be as follows
25% Creativity, originality
25% Clearly written, easy to understand, well posed question
25% Challenging problem, high level thinking requirements, degree of difficulty
25% Correct solution,� proper assumptions, reasonable answers
2. ( 50 pts)� You are designing a transdermal delivery patch for the delivery an analgesic drug.� You propose a simple reservoir diffusion controlled patch.� One of the 1st things you must do, is to determine the permeability of the drug through the skin and the rate controlling membrane on the patch.� You buy a diffusion chamber and place either 10 cm 2 of cadaver skin, adhesive film, or the� polymer barrier film between the two chambers and monitor the drug transport using HPLC.� The concentration of drug in the reservoir is 10 mg/ml (it is saturated)
�� 
Proposed system ������������������������������������������� Diffusion chamber
You obtain the following data
|
Time (min) |
Amount of drug transported across polymer membrane (ug) |
Amount of drug transported across the adhesive layer (ug) |
Amount of drug transported across the skin (ug) |
|
10 |
0.0334 |
0.334 |
0.05 |
|
20 |
0.0667 |
0.667 |
0.09 |
|
30 |
0.1 |
1 |
0.15 |
|
40 |
0.133 |
1.33 |
0.18 |
|
60 |
0.2 |
2 |
0.25 |
�
You need your system to deliver 0.2 mg/hr to maintain therapeutic� blood levels.� Will you achieve that rate with your design?��� Can you figure out a way to achieve 0.2 mg/hr?� What would be a potential problem with your system?