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October 30, 2003
E. Terry
Papoutsakis Department of Chemical
Engineering Northwestern University Evanston, IL 60208, USA
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"DNA Microarrays and A Systems Approach to Biology"
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Abstract
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Chemical & Biochemical Engineering have evolved enormously in the last 50 years, and, interestingly enough, as we enter the era of post-genomics, systems biology & genetic medicine, the two disciplines may find that they have more in common than ever before. This is well demonstrated by the development of genomic-scale expression profiling. Facilitated by the development of DNA microarrays, expression profiling allows measurement of the transcriptional response of thousands of genes to a cellular perturbation in a single assay. The expression profile constitutes a detailed molecular phenotype of the cellular state, whether it is a disease, a process such as cell division or differentiation, or a response to a chemical or environmental perturbation. Although still in its technological infancy, DNA arrays are a powerful new tool (the first of the high throughput genomic tools) that will change the way we do basic and applied biological research, IP protection and process validation. I will use recent examples (from both human- and microbial -cell systems) from my laboratory to demonstrate the power and challenges of this new tool. These challenges include computational tools to clean up, normalize, mine and use the data. Many of these tools are also extensively used in process systems engineering.
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Room: 1064 Duncan Hall . Time: 2:30 PM For more information contact: |
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