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February 26, 2004
Charles E. Nakamura
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"Metabolic engineering for the microbial production of 1,3 propanediol"
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Abstract
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Improvements in the biological production 1,3-propanediol, a key ingredient of an emerging polymer business, have been realized. Utilizing genes from natural strains which provide 1,3-propanediol from glycerol, metabolic engineering has enabled the development of a recombinant strain to utilize the lower cost feedstock D-glucose. The improvements involve 1) changing an anaerobic process to an aerobic one, 2) replacing the feedstock uptake (transport) mechanism of the host organism, 3) intergeneric transfer of complex metabolic pathways, and 4) designing and implementing an optimum solution to the balance of carbon, redox, and energy with respect to microbial growth and product formation. This accomplishment bodes well for future metabolic engineering efforts and, ultimately, for increased societal benefit obtained through production of chemicals from renewable resources.
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Room: 1064 Duncan Hall . Time: 2:30 PM For more information contact: |
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